I recently came across an article that attempts to get to the very essence of longevity and it begins by asking a simple question:
What is a clear, universal definition of the term ‘longevity’?
When you stop to think about it, this is a very intriguing question. As the article points out, the answer is not straightforward because a lot depends on who is asking the question and who is giving the answer.
In this piece, the staff at Longevity.Technology has come up with some good answers. They have defined the three targets of longevity and created four pillars of longevity intervention. They have even made a graphic incorporating the longevity pillars, drivers and domains. This helps put the whole field into perspective and gives us clues on how to attack these problems.
I am glad to say we are addressing the three targets of longevity in our state-of-the-art PUR-FORM clinic on a number of different levels and we are constantly on the lookout to change determinants by tackling our patients’ lifestyle and environment.
What I am most excited about, however, is how we continue to devise revolutionary treatments for what this article describes as aging drivers, meaning, the biological and chemical reactions that determine how and why we age.
I may sound like a broken record, but the pathways in our body determine how and why we age. Controlling or influencing these pathways can make all the difference in our aging. As the article states, these pathways are linked to each other. These pathways include IGF-1, the Sirtuins, mTOR, FOXO, and AMPK.
Fortunately, we have a number of different methods of attacking these pathways, like EBO2 treatment, which provides a host of longevity effects.
The same can be said for our high-tech cryotherapy chamber, our red light therapy and infrared sauna treatments, and our menu of a variety of intravenous supplements. As pointed out in the article, these modalities are all part of the four pillars of longevity intervention.
The first pillar the article discusses is ‘prevention’. At PUR-FORM, we’re on the leading edge of prevention with our nurse practitioner Carissa Raver, who anchors our functional medicine department. Carissa’s depth of knowledge about how the human body functions holistically allows her to spot common problems before they develop. Couple that with a variety of tests she has at her disposal, and when it comes to eliminating chronic pain, improving mood and boosting energy, we’ve got you covered.
This spills over into the second pillar of longevity, which involves diagnostics.
Longevity diagnostics may include a variety of tests spanning multiple different fields, from simple X-rays to a whole battery of blood tests.
The third pillar involves the treatment aspect of longevity. Many times, this is where I also get involved. Perhaps the patient needs a regenerative medicine procedure of a joint or treatment for an autoimmune condition. Perhaps a patient wishes to reduce inflammation in the body to reduce “inflammaging”. These treatments can include VSELs procedures, EBO2, autologous regenerative cells, IV solutions and other modalities which I have mentioned and which we will add.
The final pillar is “renewal,” which is what we are ultimately aiming for.
We want to prevent and reverse aging -- full stop. The treatments and modalities we offer at PUR-FORM will accomplish these goals in many unique ways. In addition, we have a full aesthetics division led by our exciting new physician’s assistant, Emily Carr, for those looking to enhance their beauty and grace as they age.
- Dr. P
The answer is the P-53 gene. Elephants have 20 copies of this gene while humans typically only have one.
A more common name for the P-53 gene is the “tumor suppressor gene.” It is what we call a transcription factor, meaning it has a direct effect on various genes. In this case, the P-53 gene is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions.
One of the problems with our own individual P-53 gene is that over time and through a multitude of mutations it can become ineffective.
Fortunately, we are now able to offer our patients a recombinant form of P-53 protein that is delivered via a transdermal skin patch. Recombinant means it is produced in a lab and is nearly identical to what the human body produces.
Certainly, we are not able to make any concrete claims about this patch, but I use it myself to “hedge my bets.” If you are interested in obtaining this patch, please contact our office.
In addition, here is an article from Scientific American that discusses the amazing ability elephants have when it comes to preventing cancer.
And, if you’d like to read more about the P-53 gene, you can read my complete blog post here.
– Dr. P
Thyroid. What is it? What does it do? How do I know if there’s an issue?
Your thyroid gland plays an important part in the metabolism, growth and development of the human body. The thyroid gland produces triiodothyronine T3, and thyroxine T4. With the help of the pituitary gland, the thyroid gland knows whether or not to release more or less hormones into the bloodstream. An imbalance in over or underproduction of these hormones can cause a great number of symptoms.
In a hypothyroid state, where the thyroid does not produce enough thyroid, one may experience weight gain, constipation, loss and thinning of hair, depression, fatigue, menstrual disorders and muscle aches.
In a hyperthyroid state, where the thyroid is over-producing thyroid hormones, a patient may experience weight loss, frequent bowel movements, hair loss, sweating, nervousness, heat intolerance, tremors, and a rapid heartbeat.
Experts have different recommendations regarding the testing and treatment of thyroid conditions. Regardless, functional medicine strategies are highly effective to help with low functioning thyroid issues through diet and lifestyle modifications, and addressing the root cause of the imbalance.
To find out more about functional medicine or request an appointment, you can follow this link: https://stcell.com/treatments/functionalmed.html
I recently read a fascinating article on Inside Hook’s website that I wanted to share some insights from. The article tackles issues that are very important for the fields of stem cell research and regenerative medicine. One of the more profound statements from the piece that has stuck with me is this one: “Some of the most effective anti-aging efforts take place outside of the lab, and boil down to thoughtful lifestyle adjustments.”
The focus of the article is on the Hormesis Effect. I became aware of the Hormesis Effect quite some time ago. Hormesis is defined as a dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition, which can border upon toxicity. In layman’s terms, “hormesis occurs when the body experiences a concentrated period of intense pressure.”
One thing to keep in mind is that a small amount of stress is very beneficial, while a larger amount can be detrimental. This article discusses the effective hormetic responses the body has to a variety of self-induced strategies, from intermittent fasting and exercise to intermittent hypoxia training and even heat/cold therapy.
We have applied some of these same principles to our regenerative cell procedures, such as exposing the cells to cold temperatures (4 degrees centigrade and hypoxia).
This is an excellent beginner article for people who are not that familiar with the topic of hormesis, but want to learn more about it and at the same time learn how to improve their health!
- Dr. P
Read the full article here: https://www.insidehook.com/article/health-and-fitness/healthy-hormetic-stress
State Change by Robin Berzin
Robin Berzin’s new book, State Change, takes a refreshing perspective and approach to health and wellness. As founder of Parsley Health, Berzin understands the shift happening within our healthcare system. Rather than focusing on disease treatment and symptom management, Berzin’s focus is on wellness, nutrition, and prevention. State Change highlights the impact of physical transformation on mental and emotional health. She discusses how physical signals from our bodies hold a great deal of information. In taking care of our bodies, we can experience renewed energy of the mind, and feel empowered to take health back into our own hands. This book serves as a ‘manual’ for our Integrative Practice.
Lifespan: Why We Age and Why We Don’t Have To by David Sinclair
If you’re even the slightest bit interested in maintaining health into your later years of life, then this is the book for you. In his book, Sinclair clearly illustrates what modern science has to say about the aging process. He goes into detail about technology, resources and methods we can use to slow down, stop or even reverse the aging process. Fun fact, you’ll find a great deal of crossover between what we offer at The Institute and what’s discussed in this book. We’ll guide you through all things anti-aging.
Molecules of Emotion by Candace Pert, Ph.D.
You may have heard of the term mind-body medicine. These principles are largely thanks to the work of Candace Pert, molecular biologist, also known as the mother of psychoneuroimmunology. Pert’s research gave us a radical understanding of how emotions impact the chemical processes in the body. She also played a large role in the discovery of the endorphin molecule. In her book, Molecules of Emotion, she covers her groundbreaking "Theory of Emotions," which theorizes that emotions are stored in the body at the receptors, and that healthy communication between peptides and receptors, through emotional expression, is necessary to integrate the mind and body. This book serves as a great resource to understand the importance of the daily habit and lifestyle changes recommended by our integrative practitioners.
Various Works by Joe Dispenza
Joe Dispenza is a pioneer in uncovering the potential of the human brain/body for personal improvement and healing. If you’re new to his work, You Are the Placebo is a wonderful introduction to understand the impact our beliefs have on our lives as well as our health. Breaking the Habit of Being Yourself takes this a step further and describes how our body runs off the program from our subconscious mind. After this, his book, Becoming Supernatural, brings his research full-circle and discusses how he has led individuals in drastically transforming their lives. Our provider will discuss how your subconscious can be impacting your health, and direct you on the path to transformation and optimal health.
Lifeforce by Tony Robbins
Tony Robbins book, Life Force, has become an instant bestseller. In this book, Tony Robbins outlines his personal journey with regenerative medicine, and gathers leading scientists and doctors to share information on the most cutting-edge regenerative research and technology.
While we’re celebrating our first annual Book Week at The Institute with recommendations from some of our favorite anti-aging authors, we want to remind you why you need to read in the first place.
Here are our top five reasons to pick up a regular reading habit today:
Up to 70 million Americans suffer from some form of sleep disorder. One of the most common issues people have is the inability to fall asleep quickly. Fortunately, there is a free (with a library card), non-pharmaceutical way that you can prime yourself for a solid night’s sleep that begins with a quick dive into your dreams: reading.
In addition to avoiding blue light, turning off screens or computers and keeping your room cool, reading a book, on paper with a dim light before bed is a proven method to calm your mind and signal to your body that it’s time for sleep. Reading before bed also forces your mind to focus on one task, crowding out any other “noise” that may keep you awake.
2) Stress Relief
Reading is a solitary activity. Unfortunately, it’s when we’re alone that anxiety and stressful thoughts creep into our brains. When this begins to happen, it’s common to want to shift your brain’s attention to something else. You know what works perfectly for that? Books! Diving into a great novel in your favorite genre is the best way to take your mind off of…well…everything.
Binging shows is cool sometimes. You know what’s cool all the time? Binging books. Instead of endlessly scrolling Netflix for someone else’s interpretation of a book, why not grab a book and begin creating yourself. When you read a book you’re the director and producer. The characters look how you picture them in your mind. The scenes and pace of the story follows your inner monologue. You’re in total control. And if you feel like laughing, grab a funny book. Want to be thrilled, grab a detective story. And if you’re into being scared, there’s about 30 Stephen King books waiting for you.
We live in an era where nobody trusts experts and everyone believes the news is fake. If you’re on social media you’re likely fed a steady diet of click bait and headlines to make you emotional about the latest cause du jour. But spouting headlines and repeating talking points doesn’t make you smart. It makes you a drone. You know what does make you smart? Reading books on topics that matter to you and forming your own opinion. Whether you’re a history buff or you’re curious about space travel or you’re into philosophy or biographies on business leaders, reading books allows you to not only learn about the smartest people in the room, it helps you become one.
Mental deterioration. Brain fog. Forgetfulness. These are common signs of an aging brain and they happen to all of us. In order to stave them off as long as possible, we need to exercise our minds exactly like we exercise our bodies. We need to constantly challenge ourselves and learn new things. Crosswords puzzles are great for this. Books are better. With books we can decide, at any time, to tackle a brand new subject. We can read all about ancient Rome or the pyramids. We can choose to give ourselves a course on Winston Churchill or Muhammad Ali and read their biographies and autobiographies. We can pick up an entirely new subject and read a series of books on computer science or starting a new business. Books allow us to dive into new topics and keep our minds young. Forever.
What’s the first thing that comes to your mind when you think of anti-aging? For many of us, our minds go directly to the cosmetic industry, thinking about looking younger, reducing fine lines and wrinkles. The quest to find the ‘fountain of youth’ is nothing new, but the concept of anti-aging spans far beyond its superficial connotations.
Let's first get clear on what anti-aging medicine entails. Anti-aging medicine seeks to treat the underlying cause of aging, prevent decline in health as we age, as well as alleviate symptoms of age related ailments, like arthritis, osteoporosis, dementia, stroke, etc. Ultimately, the goal is to extend an individual’s healthy lifespan. Let’s discuss a few misconceptions about aging.
It’s all in the genes
We live in an exciting time where advancements in technology and genomic research are creating major transformations in medicine, where the focus has shifted from disease treatment to disease prevention. We know that every cell in our body contains packages, or a map of DNA (chromosomes) that we inherit from our mother and father. However, new discoveries in the field of epigenetics highlight that genes aren’t the only determining factor of health and disease. An individual’s environment, behaviors, lifestyle and choices all affect the way our body reads our map of DNA. Epigenetic changes, such as diet, exercise, and lifestyle all affect the way our genes are expressed, handling situations such as immune and inflammatory regulation. Epigenetics has discovered that consumption of fast, processed, and sugary foods, exposure to toxins, and a sedentary lifestyle turns on genes that promote the production of inflammation. Inflammation disrupts the body’s regulatory process, ultimately leading to disease.
Physical and mental deterioration are inevitable
There’s a good chance you’ve heard someone say, “use it or lose it”. This sentiment also applies to both physical and mental status as we get older. The more you practice or exercise an ability, the less likely you are to lose that skill. If we do not exercise our physical bodies, we will lose strength, stamina and endurance. Strength training and exercise helps to combat deterioration of bone and muscle, and helps to retain functional integrity. Exercising mental faculties also helps to keep the brain engaged and prevent degenerative conditions.
Older adults have multiple health conditions
Many studies show that maintaining a healthy lifestyle and taking care of your health as you age can help prevent all kinds of health conditions commonly associated with age. Proper care of our physical health through exercise and nutrition, as well as mental and emotional wellbeing lead to healthier outcomes for older adults.
Science has all the answers on aging
While we have discovered a great deal about the aging process, such as why and how it happens and how to slow it down, however, there is a lot we do not know. If you’re interested in learning more on the latest cutting edge research on the aging process, David Sinclair’s book, Why We Age, and Why We Don’t Have To, is a wonderful resource.
Sleep hygiene refers to healthy sleep habits. Good sleep hygiene is
important because of how crucial getting good sleep is for your mental and
physical health, as well as your overall quality of life.
Your behaviors during the day can affect how well you sleep. Your food
and drink choices, schedule, evening routine, and many other activities all
play a part in your ability to sleep. Many of the aspects of sleep hygiene seem
like common sense, but many times common sense is not so common.
So, the question becomes:
What habits can
we develop to aid and increase our sleep? What can allow the Sandman to do his job?
Here are 5 key strategies to follow:
1. Get at Least 30
Minutes of Moderate Aerobic Exercise
People who engage in at least 30 minutes of moderate aerobic exercise
may see a difference in sleep quality that same night. Moderate to vigorous
exercise can increase sleep quality for adults by reducing sleep onset, which
is the time it takes to fall asleep.
2. But Dont
Exercise Too Close to Bedtime
Aerobic exercise causes the body to release endorphins. These
chemicals can create a level of activity in the brain that keeps you awake. To
minimize sleep onset, try to make sure your exercise session is finished at
least 1 to 2 hours (if not longer) before going to bed. This will allow ample
time for endorphin levels and body temperature to decrease and the brain to
3. Avoid Blue and
White Light At Least 1 Hour Before Bedtime
Electronics should not be used close up for approximately one hour
before going to bed. The blue light emitted by your cell phone or tablet screen
restrains the production of melatonin. Blue or white light makes us feel more
energetic and wakeful, particularly if exposed to it before or during bedtime.
The reason for this lies in the fact that our brain cells are most
sensitive to blue wavelengths. Studies prove that blue wavelengths can even
affect the blind and disrupt their circadian rhythms, even though they cant
see the color.
Red or amber light, on the other hand, is the most likely to impact
our circadian rhythm and make us sleepy. These colors make us feel calmer in
the evening and promote the secretion of melatonin. Red light before and during
sleep can prevent the groggy feeling we experience upon waking up known as
4. Avoid Caffeine
This one should be pretty obvious. Caffeine is a stimulant that
increases alertness. An afternoon coffee is okay, but try to avoid caffeine the
rest of the day. If youre going to have a diet soda at dinner, make it a
caffeine-free one. And of course, any hot tea you have should also not contain
5. Adopt a Wind
Down Routine at Night
Activities such as reading, taking a bath, or meditating can help you
relax and get ready for sleep. Get out of bed if you cant fall asleep after 20
minutes of trying. Do a quiet activity in another space until you feel sleepy.
If you have to nap during the day, keep it brief. And no naps after 3pm!
If you're just now entering into an exercise routine, we recommend
starting with aerobic activities before getting into resistance training.
Particularly for people who are older, there appears to be more benefit from
doing cardio than lifting weights. The great thing about aerobic exercise is
that anyone can do it, from beginners to high-level athletes, and there are
infinite entry points to accommodate all age ranges and ability levels.
When putting together an aerobic exercise routine, the main parameters
to consider are (1) what specific cardio activities to do, (2) how often to do
them (frequency), and (3) how long each session/workout will last (duration).
If you're looking for some inspiration, our own Dr. Purita has
shared the routine he's honed over several decades below.
Dr. Purita's Morning Exercise Routine:
My aerobic exercise routine consists of waking up at around 5:30am,
walking outdoors for about an hour, coming inside and getting on the Elliptical
machine for 20-30 minutes, then swimming for around 20 minutes. I pretty much
do this seven days a week. But Im not saying you need to jump right into this
same routine; I worked up to this over many years.
If you're new to regular exercise, I recommend following the below
cardio guidelines. But before you begin any exercise regimen, consult a doctor
(like your primary care physician) to get clearance.
Stronger Skeletal Muscles
Another truism we can apply to exercise is sound body, sound mind,
especially as we get older. Skeletal muscle has a profound effect on the brain,
due in part to certain growth factors derived from muscle. One such growth
factor is brain-derived neurotrophic factor (BDNF). BDNF supports the survival
and growth of neurons in the central and peripheral nervous systems. BDNF is
literally secreted by muscle, which helps explain why theres such a strong
connection between your muscles (and more specifically, exercise) and your
Fight Sarcopenia (muscle loss)
Aside from brain health, theres the health of the muscles themselves.
One serious, and very common, condition that comes with old age is sarcopenia. This technical-sounding term
simply refers to the wasting of your muscles, where one loses skeletal muscle
mass and strength. With sarcopenia comes a host of problems: diminished quality
of life, loss of function for everyday activities, frequent injuries, and
increased risk of disease, just to name a handful. Granted, theres no escaping
Father Time, but sarcopenia can be prevented, or at the very least delayed,
with regular exercise. Back to the use it or lose it phrase if you dont
use your muscles via physical activity, you'll essentially lose them via
Of course, exercise is also very important for weight management,
which is critical for fending off a host of diseases and maximizing quality of
life. Exercise helps you build and maintain muscle, and the more muscle you
have the more calories you'll burn throughout the day. Why? Because muscle is
highly metabolic tissue that requires a lot of energy (calories) to maintain.