Recent changes in Florida regulations now allow PUR-FORM to offer advanced exosome therapy to our patients. This allows us to provide a cutting-edge regenerative treatment that has shown promising results in clinical settings worldwide.
What makes exosome therapy at PUR-FORM unique is our proprietary PhotoBioModulation (PBM) enhancement process, which we helped develop to optimize exosome potency and effectiveness before administration.
We have integrated exosome therapy into a range of existing procedures and IV treatments, allowing us to design comprehensive protocols tailored to each patient’s needs. As one of the first practices in our region to offer both intravenous and intra-articular exosome therapy under the new guidelines, and the only one combining it with advanced PBM, we are proud to provide a minimally invasive option for chronic pain, joint degeneration, systemic inflammation, and overall cellular wellness.
What Are Exosomes?
Exosomes are tiny particles released by cells. They are typically 40-180 nanometers in size and are especially abundant in mesenchymal stem cells (MSCs). Think of them as messengers between cells.
They carry important biological materials such as growth factors, proteins, signaling molecules, and genetic material that help:
- Support tissue repair
- Reduce inflammation
- Promote normal cellular function
Unlike traditional stem cell therapy, exosome treatment does not involve live cells. This avoids concerns about uncontrolled cell growth, tumor formation, and complex storage requirements while still providing comparable or in some cases superior therapeutic effects.
Exosomes are small enough to cross biological barriers, including the blood–brain barrier. This makes them particularly valuable for neurological conditions, systemic inflammation, and localized tissue damage.
Our Photobiomodulation-Enhanced Exosomes
At PUR-FORM, we use a proprietary PBM process to “activate” exosomes using carefully calibrated light wavelengths before treatment. When exosomes absorb specific wavelengths of light, subtle photochemical changes enhance their biological activity.
Research on light-treated exosomes has demonstrated:
- Up to a 7-fold increase in their ability to promote new blood vessel formation (angiogenesis), which is critical for healing
- Significant increases in beneficial microRNA content, with some therapeutic microRNAs increasing 100-fold or more
- Enhanced wound healing, cell migration, and tissue regeneration compared to standard exosome preparations
- Improved bioavailability and effectiveness of the growth factors and signaling molecules they carry
Importantly, the PBM process enhances the natural regenerative properties of exosomes without adding foreign substances or making genetic modifications. It uses only light energy to unlock greater therapeutic potential.
For patients, this means greater healing potential, enhanced effectiveness in tissue repair and inflammation reduction, and access to an innovation available at only a small number of regenerative medicine practices.
How Exosome Therapy Is Given
Intravenous (IV) Exosome Therapy
IV exosome therapy delivers exosomes directly into the bloodstream, allowing them to circulate throughout the body and reach multiple organ systems, immune cells, and areas of inflammation or injury.
Treatments are typically administered as a slow infusion over 30 – 60 minutes under clinical supervision. Sessions are usually spaced 2 – 4 weeks apart, depending on the condition being treated.
IV exosome therapy is being used in clinical settings for:
- Neurological conditions such as stroke recovery, neurodegenerative disease, and traumatic brain injury
- Cardiovascular support after a heart attack
- Autoimmune and chronic inflammatory disorders
- Lung conditions such as COPD or pulmonary fibrosis
- Anti-aging and wellness support through improved cellular repair and reduced oxidative stress
Clinical trials have generally shown a favorable safety profile. No dose-limiting toxicities have been reported in multiple cohorts, and side effects are typically mild and temporary, such as a low-grade fever. Compared to whole cell therapies, MSC-derived exosomes appear less likely to trigger immune reactions and carry minimal risk of abnormal tissue growth.
Intra-Articular (Joint) Exosome Therapy
Intra-articular exosome therapy involves precise injections directly into the joint space or surrounding tissues. This targeted approach concentrates exosomes exactly where they are needed.
Joint-focused applications include:
- Osteoarthritis: supporting cartilage repair, reducing inflammation, and improving mobility
- Sports injuries: aiding tendon and ligament repair and speeding recovery
- Degenerative joint disease: improving function and reducing pain without simply masking symptoms
- Post-surgical recovery: supporting tissue repair and reducing inflammation
- Avascular necrosis: promoting blood vessel formation and bone regeneration
Joint injections are minimally invasive, performed under sterile conditions, and usually require little to no downtime. Most patients resume normal activity quickly.
Dosing and Typical Exosome Quantities
Exosomes are measured in billions of particles. Your body naturally contains an estimated 6 trillion exosomes circulating at any given time. Therapeutic treatments supplement this natural population with highly concentrated, specialized exosomes.
Typical clinical ranges include:
- Aesthetic and anti-aging: 1–5 billion per session
- Hair restoration: 5–10 billion
- Joint and orthopedic conditions: 10–25 billion
- Neurological conditions: 25–50 billion or more
- Systemic IV therapy: approximately 15–250 billion per infusion
Research suggests an effective range for most human treatments between 10 billion and 600 billion particles, with a median effective dose around 43 billion.
Exosome preparations are highly concentrated, often about 1 billion exosomes per milliliter. For joint injections, 1-3 milliliters typically deliver 10-15 billion exosomes directly into the joint. IV formulations may contain 250 billion particles or more for systemic effects.
Higher doses are used because exosomes distribute widely throughout the body, individual cells may absorb multiple exosomes, and exosomes are gradually metabolized over time.
At PUR-FORM, dosing is customized based on your diagnosis, body weight, overall health, and treatment goals.
Combination Therapy: Exosomes Plus IV Treatments
We often combine exosome therapy with supportive IV treatments to optimize the cellular environment and maximize results. In many cases, IV therapy is administered first to “prime” the body, followed by exosomes.
After EBO2 and Plasmapheresis
Administering IV exosomes after EBO2 (Extracorporeal Blood Oxygenation and Ozonation) or plasmapheresis can be especially effective.
These procedures:
- Filter the blood
- Remove inflammatory proteins, toxins, immune complexes, and abnormal antibodies
- Improve oxygen delivery
This creates a “clean slate,” allowing exosomes to circulate in a less inflammatory environment and deliver regenerative signals more effectively.
This sequential approach can be especially useful for chronic inflammatory conditions, autoimmune disorders, complex degenerative diseases, and comprehensive anti-aging programs.
Key Synergistic IV Combinations
We have developed several advanced combination protocols, including:
Methylene Blue (MB) + Exosomes
Supports mitochondrial energy production while exosomes provide regenerative signaling. Particularly valuable in neurodegenerative conditions, chronic fatigue, and cognitive decline.
NAD+ IV + Exosomes
Restores cellular energy while exosomes enhance tissue repair and metabolic function. Commonly used for anti-aging, neurological support, athletic recovery, and chronic fatigue.
Melatonin IV + Exosomes
A powerful antioxidant that may enhance exosome production and regenerative potency, supporting anti-inflammatory and mitochondrial benefits.
EGCG (Green Tea Extract) IV + Exosomes
A strong antioxidant that may enhance anti-inflammatory effects when delivered intravenously and paired with exosomes.
Curcumin IV + Exosomes
Reduces inflammation pathways, helping create an environment where exosomes can function more effectively.
High-Dose Vitamin C IV + Exosomes
Supports collagen synthesis, immune function, and antioxidant defense before exosome administration.
Glutathione IV + Exosomes
Supports detoxification and cellular protection, creating favorable conditions for exosome uptake.
These protocols either enhance exosome content, optimize the cellular environment, or support complementary pathways such as energy production, immune balance, and antioxidant defense.
What to Expect During and After Treatment
During Treatment
For IV therapy, you will rest comfortably while the infusion runs over 30–60 minutes.
For joint injections, the area is cleaned and prepared under sterile conditions, and the injection is performed during a brief office visit.
After Treatment
Most patients experience minimal downtime. You can usually resume normal activities the same day, although we may recommend avoiding strenuous activity for 24-48 hours after joint injections.
Some patients notice improvements within days. Deeper tissue repair and functional improvements often develop over weeks to months.
Typical Treatment Timeline
Many patients experience benefits along this general timeline:
- Days 1–7: Early reduction in inflammation and improved energy in some individuals
- Weeks 2–4: Continued tissue repair, reduced pain, improved mobility
- Weeks 4–8: Ongoing regenerative activity and symptom improvement
- Months 3–6: Often the period of maximal benefit
Safety, Quality, and Regulatory Status
Our clinic uses rigorously tested exosome preparations that undergo screening for sterility, purity, and absence of endotoxins. Each batch is characterized for particle size, concentration, and bioactivity.
Absolute contraindications include acute systemic bacterial infections. Relative contraindications, such as active malignancy under treatment, are evaluated on a case-by-case basis.
During your consultation, we review your medical history to determine whether exosome therapy is appropriate and which route of administration is best.
Exosome therapy is an emerging area of regenerative medicine. While research and clinical experience are growing, exosome products are not currently FDA-approved for the treatment of specific diseases or conditions. These statements have not been evaluated by the FDA, and individual results vary.
Is Exosome Therapy Right for You?
Exosome therapy may be appropriate if you are seeking a minimally invasive regenerative approach for:
- Chronic joint pain
- Degenerative conditions
- Systemic inflammation
- Injury recovery
- Cellular wellness and anti-aging support
The best results are typically achieved when exosome therapy is part of a comprehensive plan that may include physical therapy, nutrition, lifestyle optimization, and other supportive treatments.
Schedule a consultation at our office to learn more. We will help determine whether exosome therapy alone or in combination with advanced IV protocols is appropriate for your personalized regenerative medicine plan.
Regulatory Status
Exosome therapy is an emerging area of regenerative medicine supported by growing research and clinical experience. Exosome products are not currently FDA-approved for the treatment of specific diseases or medical conditions. These statements have not been evaluated by the FDA.
– Dr. P
