Generally speaking, as a person abuses drugs or alcohol, they deplete the natural stores of NAD+ in their body, making it more difficult for them to break down energy from food and creating a dysregulation of endocrine factors, circadian rhythms, dopamine neurotransmitters, and oxytocin signaling. It is also known to increase neuroinflammation and impair mitochondrial function. Unsurprisingly, it is also speculated that people who naturally produce lessNAD+ are more likely to develop addictions or co-occurring disorders (anxiety, depression, neurodegenerative diseases, etc.).
Because of this, there have been many studies conducted to determine if intravenous NAD+ supplementation can aid in addiction recovery. While much more research needs to be done, studies show that raising intracellular NAD+ levels may be a potential solution for managing and treating addictive behavior, as well as reducing cravings, and withdrawal symptoms.
By flooding the brain with NAD+ via IV to replenish stores of the co-enzyme, the below key effects may be provided.
1. Substances can be flushed out of the user’s system more efficiently.
2. Difficult and uncomfortable withdrawal symptoms can be reduced.
3. Physical and mental cravings for alcohol or substances can be reduced.
4. The body’s ability to produce energy more naturally can be restored, without the need for stimulants or other substances like caffeine.
Braidy N, Villalva MD, van Eeden S. Sobriety and Satiety: Is NAD+ the Answer?. Antioxidants (Basel). 2020;9(5):425. Published 2020 May 14. doi:10.3390/antiox9050425