At PUR-FORM, most weight loss patients experience remarkable results through personalized care plans. However, we understand that individual metabolic responses vary. For patients not achieving desired outcomes with traditional GLP-1 medications like Ozempic and Wegovey, we’ve developed scientifically-backed alternative strategies.
NAD+ Therapy: Metabolic Revitalization
NAD+ (Nicotinamide Adenine Dinucleotide) represents a powerful metabolic enhancement strategy. This vital coenzyme provides a holistic approach to weight management by addressing multiple physiological processes. Its unique capabilities extend far beyond traditional weight loss methods:
- Boosts resting metabolic rate, allowing the body to burn more calories at rest
- Regulates appetite through sophisticated metabolic mechanisms
- Supports muscle function, which is crucial for long-term weight management
- It is particularly effective for individuals over 40 experiencing a natural metabolic slowdown
The scientific mechanism behind NAD+ is fascinating. As we age, our natural NAD+ levels decline, potentially hampering our body’s ability to efficiently metabolize energy. By strategically supplementing NAD+, we can reinvigorate the body’s metabolic processes and support more effective weight loss.
To replenish NAD+ levels, I recommend 250 mg three times weekly for three weeks, followed by twice weekly for three weeks. In addition, take an oral NAD+ precursor supplement daily.
Intravenous EGCG: Antioxidant Weight Loss Support
Epigallocatechin Gallate (EGCG) offers a sophisticated approach to weight management through its powerful antioxidant properties. Derived from green tea, this compound provides multiple metabolic advantages when administered intravenously. The targeted delivery ensures maximum absorption and effectiveness:
- Enhances metabolism by supporting cellular energy processes
- Increases fat oxidation, helping the body more efficiently break down stored fat
- Improves insulin sensitivity, which is crucial for sustainable weight management
By choosing intravenous administration, we maximize EGCG’s bioavailability, ensuring the patients receive the most potent metabolic support possible. I recommend getting EGCG intravenously once weekly for four weeks to experience its full potential, followed by a long-term oral EGCG supplement. Here at PUR-FORM, we offer EGCG intravenously as a special order.
Alpha-Lipoic Acid (ALA)
ALA serves as a powerful natural antioxidant that activates critical metabolic pathways. Targeting the AMPK pathway, ALA helps improve cellular energy processes, enhance glucose uptake, and support efficient fat metabolism. This makes ALA an essential component of our advanced weight management approach. I recommend taking ALA once a week for three weeks. You can purchase an ALA supplement from our shop.
Curcumin
More than just a spice, Curcumin offers profound metabolic benefits. Its anti-inflammatory properties address one of the fundamental challenges in weight loss: chronic low-grade inflammation. Curcumin provides a multifaceted approach to weight loss by modulating lipid metabolism and influencing fat cell development. I recommend a dose on the first week (after passing a test to ensure no allergic problems) and repeat in two weeks. Long-term, I recommend taking an oral supplement. Here at PUR-FORM, we offer Curcumin intravenously. You can learn more about it here.
Resveratrol and Quercetin
These powerful compounds work at the cellular level to activate metabolic pathways. By influencing mitochondrial energy production and stimulating AMPK activity, they offer sophisticated support for metabolic health and weight management. I recommend intravenous dosages to be taken every other week for six weeks. You can purchase both Resveratrol and Quercetin from our shop.
Additional Metabolic Support
Berberine and Cinsulin provide targeted metabolic regulation. Berberine activates critical metabolic pathways, while Cinsulin helps stabilize blood sugar and reduce cravings. Together, they create a comprehensive approach to managing weight and metabolic health. For Berberine, I recommend a dose of 1500 mg a day. You can purchase Berberine from our shop here.
MCT Oil: A Metabolic Accelerator
Medium-chain triglyceride (MCT) oil represents a sophisticated nutritional strategy for weight management. Unlike traditional long-chain triglycerides, MCT oil offers unique metabolic advantages that support weight loss efforts. Its distinctive molecular structure enables rapid absorption and metabolism, providing immediate energy while potentially enhancing overall metabolic function. Some of it’s key metabolic benefits include:
- Rapid liver metabolism and energy conversion
- Increased thermogenesis and calorie expenditure
- Appetite regulation through hormone modulation
- Potential support for ketogenic diet strategies
The scientific mechanism behind MCT oil is fascinating. By promoting faster energy conversion and potentially increasing the body’s heat production, it creates an environment more conducive to weight loss. Moreover, its ability to trigger fullness hormones like peptide YY and leptin can help reduce overall calorie intake.
Contrave: Neurochemical Weight Management
Contrave represents an innovative pharmaceutical approach to weight loss, combining two powerful active ingredients: naltrexone and bupropion. Naltrexone is an opioid antagonist that reduces cravings by blocking the reward response in the brain associated with high-calorie foods, making it easier for individuals to adhere to a healthier diet. Bupropion, on the other hand, is an inhibitor of the neuronal reuptake of dopamine and norepinephrine, which affects neurotransmitters involved in mood and the sensation of pleasure, helping to control appetite and reduce food cravings. Contrave’s mechanism of action:
- Naltrexone blocks reward responses associated with high-calorie food
- Bupropion influences neurotransmitters related to mood and pleasure
- Targets the hypothalamus (appetite regulatory center) and mesolimbic dopamine circuit (reward system)
- Regulates food intake and energy balance
By addressing both the physiological and psychological aspects of eating, Contrave offers a comprehensive strategy for individuals struggling with traditional weight loss methods. This dual action helps regulate food intake and energy balance, although the exact neurochemical effects leading to weight loss are not fully understood. The medication is typically prescribed alongside a reduced-calorie diet and increased physical activity to enhance its effectiveness. Clinical trials have demonstrated significant weight loss potential when combined with lifestyle modifications.
Intermittent Hypoxia Therapy: Cellular Metabolic Optimization
Intermittent hypoxia therapy represents a cutting-edge approach to metabolic enhancement. By strategically exposing the body to controlled periods of reduced oxygen, this therapy triggers profound cellular adaptations that support weight loss and overall metabolic health. The comprehensive metabolic benefits include:
- Stimulates mitochondrial biogenesis and efficiency
- Upregulated fatty acid oxidation and glucose metabolism
- Enhances fat metabolism and energy utilization
- Improves cardiovascular function and blood vessel growth
- Increases nitric oxide production
- Reduces inflammation in the cardiovascular system
These effects collectively contribute to improved heart health and exercise capacity. Intermittent hypoxia can increase fat metabolism and lead to more significant weight loss and reduction, especially when combined with a balanced diet and regular exercise. Improved insulin sensitivity and glucose metabolism, as observed with intermittent hypoxia, can help manage blood sugar levels and reduce the risk of metabolic disorders like type 2 diabetes. The suppression of appetite and increased basal metabolic rate associated with intermittent hypoxia therapy further support weight loss efforts and maintain a healthy body composition.
This therapy’s impact extends beyond simple weight loss. By activating the hypoxia-inducible factor (HIF) pathway, it promotes complex physiological adaptations that improve overall metabolic function. The increased production of vascular endothelial growth factor (VEGF) supports improved blood flow and tissue oxygenation.
Whole-Body Cryotherapy: Metabolic Reset Through Cold Exposure
Whole-body cryotherapy (WBC) offers a revolutionary approach to metabolic enhancement and weight management. By exposing the body to extreme cold temperatures ranging from -110°C to -150°C, this therapy triggers remarkable physiological responses that support weight loss and metabolic optimization. Some of the metabolic transformation mechanisms include:
- Stimulates metabolic rate through heat generation
- Promotes conversion of white adipose tissue (WAT) to brown adipose tissue (BAT), which burns calories to produce heat
- Influences hormone and protein secretion related to fat metabolism
- Supports body composition improvements
When exposed to extreme cold, the body initiates complex survival mechanisms that increase calorie expenditure and metabolic efficiency. The process of “browning” adipose tissue represents a particularly intriguing metabolic adaptation, transforming energy-storing tissues into active calorie-burning components.
These changes can reduce body fat, particularly in specific areas like the abdomen. Some studies have demonstrated that repeated cryotherapy sessions can decrease body fat mass and alterations in adipose tissue distribution, with reported reductions in waist circumference and improvements in cholesterol and blood sugar levels. Despite these potential benefits, cryotherapy is not a standalone solution for significant weight loss. It should be combined with lifestyle changes such as diet and exercise for optimal results.
Hydrogen Therapy: Cellular Metabolic Optimization
Inhaled hydrogen gas emerges as a sophisticated strategy for metabolic health and weight management. Its powerful antioxidant and anti-inflammatory properties offer a nuanced approach to supporting metabolic function. Some of its key metabolic benefits are:
- Activates Nrf2 pathway for enhanced metabolic processes
- Reduces oxidative stress and inflammation
- Improves glucose and insulin metabolism
- Supports fatty acid expenditure
Moreover, hydrogen therapy has been noted to have therapeutic effects in various disease models, including obesity and diabetes. It has been shown to improve metabolic parameters such as plasma glucose, insulin, and triglyceride levels, similar to the effects of diet restriction. These improvements suggest that hydrogen gas could play a role in managing obesity and metabolic syndrome by enhancing fatty acid and glucose expenditure. Its ability to modulate metabolic parameters offers promising potential for comprehensive health management.
Peptide Therapy
Peptide therapy represents a highly individualized approach to metabolic enhancement. Unlike one-size-fits-all solutions, these targeted molecular interventions can be customized to address specific metabolic challenges and weight management goals.
Our approach recognizes that each patient’s metabolic profile is unique. Peptide therapies offer a precision-based strategy that can be tailored to individual physiological needs, providing a more nuanced approach to weight management.
Comprehensive Metabolic Transformation
While these innovative therapies offer exciting potential, they are most effective when integrated into a holistic approach to health. Diet, exercise, lifestyle modifications, and personalized medical guidance remain critical components of successful metabolic optimization.
Your Path to Metabolic Wellness
At PUR-FORM, we understand that weight management is a complex, personal journey. Our advanced therapeutic strategies represent more than just treatments–they are scientifically crafted pathways to comprehensive metabolic transformation. We don’t just aim to help you lose weight; we strive to optimize your body’s fundamental metabolic processes.
Every individual’s metabolic landscape is unique, and our expert is dedicated to designing personalized strategies that align with your specific health goals. Through cutting-edge therapies, comprehensive assessments, and compassionate care, we empower you to unlock your body’s full metabolic potential.
If you’re interested in exploring your personal metabolic enhancement journey, schedule a consultation with our expert nurse practitioner, Thomas Chesney, here and discover the advanced strategies that can transform your approach to weight management and overall health.
Disclaimer: This article is for informational purposes only. Always consult a healthcare provider before beginning any new supplement or therapy.
-Dr. P
