The three above supplements are extremely important for optimal health but unfortunately, we have problems with their absorption. We may diligently take them orally on a daily basis which certainly helps but many times that may not be sufficient. However, if we are able to supplement our daily oral doses with Intravenous applications then we are talking about something special. We have been searching for Intravenous or injectable forms of these compounds for some time now and have finally found reliable sources. When something is delivered via an Intravenous route (IV) there is instant and significant absorption. Many times, the same can be said for an intra-muscular (IM) route as far as absorption is concerned. We are happy to report that these three compounds will now be an integral portion of our repertoire. The centers that have access to all these compounds are few and far between. The main problem with most of these compounds is their bio-availability. We can take them by mouth but how much of them will we absorb is a different story. This is the situation with many supplements and for that matter medications. The science of how compounds are absorbed is called pharmacokinetics. Pharmacokinetics involves the absorption, distribution, metabolism, and excretion of a compound.


All About Coenzyme Q10

Coenzyme Q10 is a member of the ubiquinone family of compounds. All animals, including humans can to some degree synthesize ubiquinones, hence, Coenzyme Q10 is not considered a vitamin. The name ubiquinone refers to the ubiquitous presence of these compounds in living organisms and their chemical structure, which contains a functional group known as a benzoquinone. Coenzyme Q10 is soluble in lipids (fats) and is found in virtually all cell membranes including the mitochondrial membrane. Remember that the cell membrane represents the eyes and ears of the cell. It interacts with the environment. Co Q10 is present in every cell of your body. However, the highest concentrations are found in organs with the greatest energy demands, such as the heart, kidneys, lungs and liver. Co Q10 is a fat-soluble, vitamin-like compound that seems to have many health benefits. As we can see from the following diagram it is vital for the production of energy in the body while at the same time serving as an anti-oxidant. It does this crucial work by its effects on the electron transport chain. The ability of Coenzyme Q 10 to accept and donate electrons is a critical feature to its function.

Figure 2. Mitochondrial Electron Transport Chain. Coenzyme Q10 is a lipid-soluble component of the mitochondrial inner membrane that is critical to electron transport (in red) in the mitochondrial respiratory chain. Coenzyme Q10 carries electrons from complexes I and II to complex III, thus participating in ATP production.

These properties make it helpful in the preservation of cells and the prevention and treatment of some chronic diseases. It’s critical to add Co Q10 supplements as you age. After the age of 30, your natural levels of Co Q10 begin to diminish. By the age of 50, this depletion of Co Q10 continues to accelerate. By age 70, your natural Co Q10 levels may be 50% lower than they were when you were a young adult. It is widely known that statins severely deplete your body’s natural levels of CoQ10, which can be very dangerous. A Columbia University study found that within 30 days, your levels of Co Q10 can be decreased by half. However, statin drugs aren’t the only culprit. In fact, there is a long list of pharmaceuticals that rob your body of Co Q10. Nearly 50% of American adults take at least one prescription daily, it’s more important than ever to supplement with Co Q10 so you can be sure your body has the necessary levels needed for proper cellular energy function and a strong cardiovascular system. Co Q10’s health benefitsare far reaching. We now have an injectable form of Co Q10 that will dramatically increase the amount of Co Q10 the body will absorb. This will pay the patient many health dividends including better health, more energy and less sickness. Remember that mitochondrial dysfunction is the basis of many diseases. Co Q10 fights mitochondrial problems making the mitochondria healthier enabling them to ward off diseases.


What Is Quercetin? - Quercetin Supplement Health Benefits & Risks group

Quercetin-type Flavonols, the most abundant of the flavonoid molecules, are widely distributed in plants. Remember that a flavonoid is a group of plant chemicals found in fruits and vegetables.

They give fruits and plants their color and smell. Flavonoids are powerful antioxidant agents that help regulate cellular activity. They are found in a variety of foods including apples, berries, Brassica vegetables, capers, grapes, onions, shallots, tea, and tomatoes, as well as many seeds, nuts, flowers, barks, and leaves. Quercetin is also found in medicinal botanicals, including Ginkgo biloba, Hypericum perforatum, and Sambucus canadensis. In red onions, higher concentrations of quercetin occur in the outermost rings and in the part closest to the root, the latter being the part of the plant with the highest concentration. Quercetin in the pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. Quercetin possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and Anti-aging.

These aspects are evident in the following diagram:



The above diagram shows the main mechanism of Quercetin’s actions namely reducing oxidative stress. Oxidative stress is what I call an upstream cause of aging. If we control oxidative stress than we can eliminate or significantly alter the course of many degenerative diseases while at the same time slow down the clock of aging. As we can see, Quercetin is attacking some of the upstream pathways of aging. Although Quercetin is very powerful, the problem is delivering it to the places where it is needed. To improve the bioavailability of Quercetin, numerous approaches have been undertaken. These involve the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles also called micelles, which appear to provide higher solubility and bioavailability. If we can enhance bioavailability of Quercetin in the future, then it is likely to bring this product to the forefront of therapeutic agents for treatment of human disease. The fact that we can now deliver it via an intravenous route makes these other drug delivery systems not be as important. Certainly, they can be convenient, but at present they cannot compete with the intravenous route as far as absorption and efficacy are concerned. This is a monumental step.

In addition to the beneficial aspects already mentioned for Quercetin there is one other huge benefit. This benefit concerns the aspect that Quercetin has on Senescent cells. A Senescent cell is essentially a cell that should have died but continues to live. It has lost its ability to reproduce. It secretes a number of undesirable growth factors which encourage a variety of degenerative conditions and other health problems. Quercetin will act as a Senolytic agent. A Senolytic agent helps to clear out the Senescent cells. If we eliminate Senescent cells than we eliminate their growth factors which can cause havoc. In our office when we are utilizing NAD+ we make it standard practice to give the patient some Quercetin to help keep the Senescent cells at bay rather than encourage their health. We do need some Senescent cells but only in small numbers. Quercetin is a good protector from Senescent Cells.


Curcumin and Cancer - Cancer Therapy Advisor

Turmeric is a spice that has long been recognized for its medicinal properties. It has received interest from both the medical/scientific world as it is the major source of the curcumin. Turmeric is a spice derived from the rhizomes of the tropical plant Curcuma longa Linn, which is a member of the ginger family (Zingiberaceae). The bright yellow-orange color of turmeric comes mainly from fat-soluble pigments known as curcuminoids. Curcumin, the principal curcuminoid found in turmeric, is generally considered its most active constituent. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people and athletes. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, Piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Personally, I have found the best form of oral form of Curcumin come from a product called Ultra Cur. The uniqueness of Ultra Cur comes from the whey protein scaffold on which Ultra Cur is delivered into the body. This scaffold dramatically increases the bioavailability. But we still must realize that an intravenous form will far surpass the bio absorption of any oral forms.

The diagram below shows the far-reaching medical benefits from Curcumin:

How Long Does It Take To Feel The Benefits of Turmeric? - Me First Living

When discussing Curcumin from scientific point we need to address what pathways of aging it seems to address.

The following diagram shows some of these pathways:

IJMS | Special Issue : Curcumin in Health and Disease

In some of the pathways above we are able to see some significant pathways related to aging. One important pathway mentioned above is the NFkB pathway. This pathway is a master regulator of inflammation in the body. If it is stimulated it causes inflammation to get a foothold possibly resulting in many degenerative diseases and conditions. The Th-1 response results from our immune system. This portion of our immune system can result in autoimmune conditions. We need to remember many diseases may have their roots in an auto immune condition. The blocking of the COX-2 pathway is the mechanism of how many anti-inflammatories work. Increasing the amount of BDNF has many profound implications. BDNF plays a critical role in preventing cerebral atrophy and cognitive decline. We also know that BDNF has profound effects on muscle tissue. It helps muscles repair themselves, preserve their integrity, and prevent the typical decline we see with advanced age. We see Curcumin increases antioxidative enzymes which will help eliminate free radicals and the damage they cause. Lastly, there are many studies underway looking at the inhibition of cancer growth.

The next diagram shows some other aspects of Curcumin:

Frontiers | Curcumin as an Alternative Epigenetic Modulator: Mechanism of  Action and Potential Effects | Genetics

What is of great significance in this diagram is the fact that Curcumin acts as a transcription agent. A transcription agent will typically turn on genes that have become silenced due to a variety of reasons. In this case Curcumin will activate the P-53 gene. This gene is called the Tumor Suppressor Gene. This gene is on patrol to analyze cells as far as DNA damage is concerned. The diagram below explains the P-53 gene in simple terms. If the P-53 is not working properly than it allows cells with accumulated DNA damage to persist and possibly go on to cause degenerative diseases and cancers. When it is working properly than it eliminates the bad cells and repairs those cells worth repairing. We can see the far-reaching effects that Curcumin has upon our health and well-being.

Thus, we can see the multiple benefits that we can offer from the use of Intravenous Quercetin and Curcumin and injectable Co Q10. They would seem to be especially helpful as an adjunct to NAD+ and other treatments. I still believe in taking oral forms of these compounds but there is no doubt that we occasionaly need to supplement them with Intravenous or Injectable forms. Your life, health, and well being many depend upon it.


Dr. P


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