colorful cells
Regenerative Medicine



I feel quite privileged to work with Dr. Jo Serrentino.  She is my colleague, a mentor, and a partner.  She and I have been working on a few cutting edge of the cutting edge projects for a number of years.  There is no doubt that her knowledge and inspiration have helped me design some very unique protocols.  She is a fountain of knowledge.   One day I may ask her how we can increase the effectiveness of stem cells injected into a joint.  On another day I might call her up to discuss some aspect of a V cell treatment that potentially increases the overall effectiveness of the treatment.  She has been instrumental in helping us develop our protocol for the treatment of Osteoporosis with stem cells and different growth factors.   Although our series is still small we are obtaining improvements of from 15-30% in bone density values in one year.

I am most beholding to Dr. Serrentio for her guidance and teaching of cytokine therapy. ¬†Most every condition in medicine typically results from an imbalance in cytokines. ¬†If you are dealing with an osteoarthritis, tendinitis, or an autoimmune disease you can be sure that an imbalance of cytokines is at work. ¬†Cytokines are a broad and loose category of small proteins that are important in cell signaling. Their release has an effect on the behavior of cells around them. ¬†They are very involved with our immune system and help regulate it and balance it out. ¬†In Regenerative Medicine our immune system is of the upmost importance controlling the body’s reactions. Cytokines and the immune system regulate the maturation, growth, and responsiveness of particular cell populations. ¬†Some cytokines enhance or inhibit the action of other cytokines in complex ways. ¬†We have used cytokine therapy to enhance our procedures for a number of years now. ¬†I repeatedly get asked the question “am I too old for stem cell therapy?” The answer to this is a resounding no when we are also utilizing Cytokine therapy. ¬†This is one of our secret weapons. ¬†A good clinical example of this is concerning a simple PRP injection. ¬†As we age the levels of Insulin Growth Factor-1(IGF-1) decrease significantly.¬† IGF-1 is instrumental in the repair of cartilage tissue, tendons, etc. ¬†However, if you are starting with low levels because of age or advanced osteoarthritis the repair of that joint may not be forthcoming.¬† This is the beauty of Cyto-Amino-therapy as Dr. Serrentino calls it.¬† We can help correct these deficiencies and encourage repair.¬† Age is no longer an insurmountable road block.

Cytokine Intercellular Communication

I asked Dr. Serrentino to write about cytokine therapy in her own words. ¬†She wrote the following summary for me: “Because cytokines are for research purposes only, they cannot be used liberally in commercial products. The controversy over growth factors for example has been ongoing for decades; restrictions in using these valuable signaling molecules in medicine is still an ongoing issue, despite the research data proving their countless benefits and safety”.¬† Therapy with signaling molecules or Cytokine Therapy as coined by the researcher who developed the modality, Dr. Serrentino, is indeed a boon to modern medicine.¬† For example, the use of recombinant proteins such as IGF-1 to repair cartilage in osteoarthritis, or the use of recombinant Interleukin -10 as an anti-inflammatory can dramatically alter the results of a procedure. ¬†Hundreds of protocols have been established by Dr Serrentino, but the availability of actual Cytokines in the right combination and dosage has been difficult to source and to regulate. ¬†Sources of real cytokines in commercially available products are usually from homeopathic sarcodes or nosodes, (a sarcode comes from an animal part) but these provide only the precursor components not the real thing according to Dr. Serrentino. ¬†Recent advances in technology have enabled Dr. Serrentino to develop clones of signaling molecules that have shown better biological action than actual cytokines. ¬†Dr.¬† Serrentino has coupled polyamino molecules with nano technology to create Cyto-amino¬ģ Complexes that mimic the signals and the biological activity of many cytokines.

Dr Serrentino further explains that: ¬†‚ÄúBecause these Cyto-amino complexes are engineered through nano technology, they do not work like a supplement but rather go directly to the extracellular matrix where they signal cellular tasks.¬† Just like cytokines they tell the cells where to go and what to do.¬† Amino acids are the building blocks of proteins, and cytokines are small proteins, so we can synthesize a clone through certain biochemical techniques with readily available amino acids. But these new molecules are not supplements of amino acids, they do not work like supplemental amino acids. They have a unique structure that gives them the capacity to mimic the action of a bonafide cytokine with extreme precision. They are not dependent on serum levels or need to be broken down like supplements, they work exactly like cytokines at signaling pathways, thus we can use them to program repair, which is the basis of Cytokine Therapy. ¬†This Cyto-amino Complexx ¬ģ goes straight to the extracellular matrix where it gives

cells directions in programming regenerative pathways. ¬†CYTO-AMINO COMPLEXES ¬ģ can provide some extremely effective practical products for medical therapy, especially regenerative medicine and stem cell therapies. ¬†Exclusive formulations have been developed for Dr Purita‚Äôs Stem Cell techniques and protocols and are solely available through his teaching venue.”

Every day I continue to learn the intricacies of cytokine therapy.  This therapy is truly unique in all stem cell therapy.  As time goes on I am sure Cytokine Therapy will continue to make a difference not just in my practice but in that of a fortunate few others.  In some circles there is a notion that stem cells are but a waypoint in our treatment modalities.  Eventually, cytokine therapy may replace harvesting stem cells. Remember, cytokine therapy mimics stem cell therapy in a much more efficient way.  Perhaps I should say in a different manner: Stem cell therapy tries to mimic Cytokine therapy.  We will certainly hear more of this as time goes on.  Thanks Dr. P


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