Bryan Johnson, known for his rigorous biohacking experiments, recently shared remarkable results after completing 60 Hyperbaric Oxygen Therapy (HBOT) sessions. While I don’t necessarily agree with everything Johnson promotes, his observations about HBOT align with growing scientific evidence supporting HBOT for health optimization and longevity. Let’s examine the key benefits he reported and what science tells us:
- Reduction in Systemic Inflammation: Johnson noted that HBOT eliminated systemic inflammation to below-detectable levels. This finding is consistent with studies showing HBOT reduces pro-inflammatory cytokines such as TNF-α and IL-1β, which are key contributors to chronic inflammation. Whether inflammation comes from viruses or autoimmune conditions, HBOT helps combat it by reducing oxidative stress and calming inflammatory responses throughout the body.
- Increase in Vascular Growth Factors: A 300% increase in VEGF (Vascular Endothelial Growth Factor) was reported, facilitating angiogenesis–the formation of new blood vessels. This process enhances oxygen delivery to tissues and supports repair mechanisms. Research confirms that HBOT boosts VEGF and hypoxia-inducible factor 1-alpha (HIF-1α), both crucial for vascular health and regeneration.
- Telomerase Activity and Cellular Aging: Johnson observed telomerase activity (an enzyme that maintains protective caps on chromosomes) comparable to that of a 12-year-old. This suggests significant biological age reduction. HBOT increases telomere length, protecting chromones from degradation. I suspect he likely used a technique that involves “air breaks” – developed by Israeli researchers where patients alternate between high-oxygen exposure and regular air breathing during treatment sessions. These oxygen fluctuations activate pathways that help maintain youthful cellular function. I have previously written a blog on this topic which you can read here.
- Gut Health Improvements: The therapy led to a remarkable 250%-290% increase in short-chain fatty acids (SCFAs) like n-butyrate in Johnson’s gut microbiome, reflecting better gut health. These compounds are crucial for intestinal health, immune regulation, and reducing inflammation–all important factors for overall well-being and longevity.
- Elimination of Metabolic Imbalances: HBOT helps restore metabolic balance by improving mitochondrial function–your cells’ energy factories. By enhancing oxygen delivery, HBOT increases energy production (ATP), improves cellular metabolism, and supports repair mechanisms. Along with related therapies such as Intermittent Hypoxia Therapy (IHT) and Extracorporeal Blood Oxygenation and Ozonation (EBO2), it activates the AMPK pathway, improving glucose tolerance and metabolic health.
- Brain Health Support: Johnson saw a 28.6% reduction in dementia-related markers, suggesting significant brain benefits. Research shows HBOT protects brain cells by improving oxygen supply and reducing harmful oxidative stress–key factors in maintaining cognitive function and preventing neurodegenerative conditions.
- Muscle Recovery Improvements: The increased oxygen delivery during HBOT sessions optimizes muscle recovery and performance. It does this by increasing energy production within muscle cells and reducing damage from free radicals.
- Skin Health Improvements: Johnson reported substantial improvements in skin elasticity and overall appearance. HBOT stimulates collagen production (the protein that gives skin its structure), accelerates healing, improves skin tone, and reduces oxidative stress–all contributing to visible anti-aging effects.
Bryan Johnson’s remarkable results, supported by scientific evidence, show that HBOT offers a powerful approach to enhanced health and longevity. If you’re looking to reduce inflammation, improve brain function, rejuvenate your skin, and boost overall vitality, HBOT presents a compelling option.
At PUR-FORM, we’ve developed proprietary methods to further enhance the results of HBOT. Contact our office today to schedule a consultation and discover how this therapy can help you achieve a healthier, more vibrant you.
-Dr. P
