THE SCIENCE BEHIND COVID-19 AND CUTTING-EDGE METHODS FOR BOOSTING IMMUNITY: A COMPREHENSIVE PAPER
April 5, 2020
Just exactly what is the novel Coronavirus and how is it different from the regular flu? Seasonal flu is an “all human virus”. The DNA/RNA chains that make up the virus are recognized by the human immune system. This means that your body has some immunity to it before it comes around each year. Immunity is obtained in one of two ways. You obtain it through exposure to a virus, or by getting a flu shot. Novel viruses typically come from animals. Usually these viruses only transfer from animal to animal (pigs in the case of H1N1) (birds in the case of the Spanish flu). But once, one of these animal viruses mutates, and starts to transfer from animals to humans then it’s a problem. Why? Because we have no natural or acquired immunity. The RNA sequencing of the genes inside the virus isn’t human, and the human immune system doesn’t recognize it so, we can’t fight it off. Many times, when the virus jumps from an animal to a human it does not have the ability to jump and infect another human. However, when the virus mutates then jumps from a human to a human we have a contagion phase which is what we are now experiencing with the Covid-19 virus. This seems to be the mechanism of the Covid-19 virus that began in an animal market in Wuhan China. Humans have no known immunity to this virus and thus initially no medicines have effectiveness with Covid-19. We now have some knowledge of the Covid-19 virus. The good news is that it still behaves similar to other viruses so we have some basis for treatment. I have covered some of these techniques in some of my other blogs so please excuse the redundancy.
WHAT ARE THE COMPONENTS OF OUR IMMUNE SYSTEM
Becoming symptomatic from the Covid-19 virus depends on how our immune system responds to the problem. One may only have the sniffles or one could end up in the ICU and be gravely ill. Our immune system consists of two main parts. One is called the innate immunity while the other is called adaptive immunity. The following illustrations show the differences between these two systems.
In the first diagram we see the two types of immune systems. The innate system is immunity that is naturally present and is not due to prior sensitization to an antigen from, for example, an infection or vaccination. While adaptive immunity is activated by exposure to pathogens such as the Covid-19, and uses an immunological memory to learn about the threat and enhance the immune response accordingly. The second diagram shows the innate immune response and adaptive immune responses of a Covid-19 infection. The Covid-19 infects macrophages (a form of white blood cell), and then macrophages present Covid-19 antigens to T cells (an immune cell). This process leads to T cell activation and differentiation, including the production of cytokines associated with the different T cell subsets followed by a massive release of cytokines for immune response amplification.
WHERE DO THE PROBLEMS START ARISING ESPECIALLY IN THE ELDERLY?
Let us discuss immunity more in lay terms. Our immune systems have two sets of defenses against viruses and other pathogens. Our first-line army of cells are called leukocytes (WBCs). They attack invading microbes within minutes to hours, and a second-line force of precisely targeted antibodies and T cells that surge to the battle front as late as several days after. The problems start arising when either the patient has some predisposing condition which weakens his immunity or age is catching up to him. We call the phenomena of aging of the immune system Immunosenescence.
With advancing age, the body has fewer T cells, which produce virus-fighting chemicals called cytokines. By puberty, the thymus gland is producing tenfold fewer T cells than it did in childhood. By age 40 or 50, there is another tenfold drop. That leaves the body depleted of T cells that have not yet been programmed to defend against a specific microbe. Fewer such “naïve T cells” means fewer able to be deployed against a never-before-seen microbe such as the Covid -19. These T cells are battle hardened soldiers but they are exposed to an enemy they have no experience with. It was as if our army were to wage battle against aliens. Complicating the problem, there are fewer soldiers that are dealing with attackers that they never experienced before, namely the coronavirus. The body does retain the “memory T cells” that learned to fight attackers in youth, which is why immunization against smallpox and many other viral diseases lasts decades. Even before T cells enter the fray, other cells recognize invaders and dispatch natural killer cells and other soldiers to destroy as many as possible in the first few hours after infection. Then these same front-line cells literally show the virus to T cells, saying in essence, this is the enemy and instructing them to produce virus-killing compounds. But this communication doesn’t work as well as we get older. The instructor cells grow scarce and start giving garbled messages. T cells response is too little and too late. Antibodies are made by B cells, and their decline is less precipitous than the fall-off in T cells. But older B cells can’t produce as much of the antibodies as when they were new. Specifically, they have lower levels of the molecules that rearranges their genome so as to produce never-before-seen antibodies to a never-before-seen virus. THE BOTTOM LINE IS THAT NOT CHRONOLOGICAL AGE ALONE DETERMINES HOW ONE DOES IN THE FACE OF A LIFE-THREATENING INFECTION SUCH AS COVID-19. Having multiple chronic diseases and frailty is in many ways as or more important than chronological age. An 80-year-old who is otherwise healthy and not frail might be more resilient in fighting off infection than a 50-year-old with many chronic conditions. The reason is that the older person may have a younger immune system.
OZONE: ONE OF THE ALLIES TO STRENGTHEN THE IMMUNE SYSTEM AND FIGHT THE VIRUS
We are very fortunate to have one of the only EBO2 machines available on the east coast. EBO2 stands for Extracorporeal Blood Oxygenation Therapy. This machine is essentially a dialysis machine that utilizes ozone rather than water to perform a “dialysis” procedure. We are not targeting kidney patients but rather a wide variety of the population from professional athletes to the average citizen. Typically, we perform EBO2 to enhance general health and for anti-aging principles. But with the current situation our emphasis has shifted a bit but in the long run the goals are still the same. We are looking for methods to boost our immune system and medical Ozone is one way to do this.
There is much scientific literature on the use of medical ozone to help eliminate viruses. For more than 100 years, ozone has been considered a virus killer in the nature. It has been widely used by people for disinfection, sterilization, deodorization, detoxification, storage, and bleaching tanks due to its strong ozonating properties.
The virus found in Wuhan and SARS (which respond well to Ozone therapy) virus both belong to the Coronavirus family. Researchers found that the Covid-19 virus is 80% similar to the SARS virus in their genome sequences. It is reasonable to predict that ozone is equally effective in preventing and controlling the new Coronavirus. Most research efforts on ozone’s viricidal effects have centered upon ozone’s propensity to break apart lipid molecules at sites of multiple bond configuration. Once Ozone interacts with these compounds it produces compounds called Ozonides. Indeed, once the lipid envelope of the virus is fragmented, its DNA or RNA core cannot survive. The following diagram shows this quite well.
There are a number of different methods of utilizing medical ozone. However, we only utilize the intravenous method. We utilize a machine called the EBO2 machine. I wrote a detailed blog about the EBO2 machine and its mode of action (blog is found in website stemcellorthopedic.com). The EBO2 has a variety of benefits for the body but for now we will limit out comments to its anti-viral abilities. With EBO2 the entire blood supply passes a number of times thru a dialysis filter after the blood is automatically mixed with ozone gas. Not only are we stimulating the immune system with the ozone but we are also killing viruses in the blood. The unit allows extracorporeal blood oxygenation, ozone exposure and blood filtration. The Ozonides also seem to have a significant effect on cytokine production. Cytokines are messenger molecules that seem to have a significant effect especially on cells of the immune system. The importance of cytokines cannot be understated. Essentially all medical conditions are a result of an imbalance of cytokines. The reaction of the immune cells to the Ozonides causes an increase in cytokine production enabling the body to kill viral cells, kill microbes including the dreaded Lyme’s disease, and potentially cancer cells. Ozone is a potent regulator of the immune system. This means that when the immune system is activated (autoimmunity), ozone will calm it down. Also, when the immune system is depleted (infections, cancer, etc.), ozone will stimulate it. This occurs by ozone’s unique interaction with white blood cells to release immune messenger cytokines. These cytokines are ultimately produced by cells of the immune system. The Ozone therapy stimulates various pathways in the body that specifically deal with oxidative stress and its ramifications. Most of the serious pulmonary and other health problems caused by the Covid-19 virus develop from a phenomenon called a “CYTOKINE STORM”. A cytokine storm occurs when there is excessive immune response between cytokines and immune cells. The symptoms are high fever, redness, swelling, extreme fatigue and nausea, which can be fatal in some cases. The following two illustrations show aspects of a cytokine storm. The second diagram shows the damage that occurs in the body.
The goal of our Institute is to prevent the patient from ever reaching the point where they are close to a cytokine storm. This is accomplished by a sort of balancing act. If the immune system is stimulated too much the storm will develop. There is too much inflammation which is causing oxidative damage which results in tissue damage. Many infections including the Covid-19 virus overwhelm the body by the production of Reactive Oxygen Species (ROS) which are very similar to free radicals. The reactive oxygen species are the contributors of oxidative stress which lead to various diseases and disorders such as cardiovascular disease, cancer, aging, and various neurodegenerative diseases. In the case of Covid-19 we see mainly pulmonary and kidney problems. The best way to prevent oxidative damage is to fight it with powerful anti-oxidants. This is where EBO2 therapy shines. Most battles in the body are a result of a tug of war in various pathways in the body.
One very important pathway is called the NRF2 pathway (nuclear factor-erythroid 2-related factor 2). The NRF2 pathway is the master regulator of antioxidant, detoxification and cell defense gene expression. It regulates over 600 genes involved in cellular protection and anti-oxidant defenses. It modulates numerous genes responsible for cognitive processes, inflammatory responses, rebuilding tissue, immune system response. The Nrf2-mediated antioxidant system is essential to protect the lungs from oxidative injury and inflammation. Furthermore, NrF2 stimulates another pathway called the NQ01 pathway. The Nq01 is intimately involved with NAD production and insures a proper NAD/NADH ratio. of antioxidant, detoxification and cell defense gene expression. Considering the significant impact of the Nrf2 pathway on the pathophysiology of both host cell and virus, Nrf2 modulators may be able to serve as a promising supplement for viral diseases by therapeutic modulation of virus-induced oxidative stress in the near future. Well the future is here in that EBO2 is a potent stimulator of the NrF2 pathway. The NrF2 pathway seems to inhibit another very important pathway called the NF-κB-r pathway. NF-κB has long been recognized as a point of convergence of inflammation, aging and disease. Remember, all diseases including the Covid-19 virus really either get eliminated or get a foothold by their effects on various pathways in the body. Below is an illustration of the NrF2 pathway and its’ relationships to other pathways.
As we can see, the EBO2 machine and Ozone can work in two distinct ways. First, there is the ability to actually kill viruses in the body by destroying their protective coating. Secondly, and perhaps more importantly they remove the “stranglehold of oxidative stress” on the immune system thus allowing it to more efficiently perform its job.
One final note on Ozone therapy. On March 24 the following letter was written. “After evaluating possible insights, the letter signed by Dr. Luigi Bertinato, Head of the President’s Scientific Secretariat, says that since the proposal to use oxygen ozone “is supported by clinical centers experienced in the treatment of viral pneumonia, the Istituto Superiore di Sanità considers it appropriate that the treatment itself can be carried out, after acquiring the patient’s informed consent. Essentially, the Italian government feels Medical Ozone seems to have great promise in the treatment of Covid19.
NAD, AN IMMUNE BOOSTER
Another very important aspect of EBO2 is the effect it has on NAD production and subsequent stimulation of the Sirtuin genes. We take this one step further by supplanting the NAD produced by the EBO2 with intra venous delivery of NAD. Mounting evidence points to NAD+ as one of the major modulators of immuno-metabolic circuits, thus regulating immune responses and functions. Recent studies show impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishment as an avenue to ameliorate deleterious inflammatory responses. Besides playing key roles in various cellular enzymatic reactions and signaling pathways, mounting evidence suggests that NAD+ dictates the host’s innate and adaptive immune responses. Thus, the evidence is fairly convincing that NAD+ may have significant beneficial effects on our immune system. For this reason, it is one of our weapons in boosting immunity.
NIH has a clinical study that has been completed but not yet published to study NR’s positive effects on healthy peoples innate immune systems. There are two types of immune systems the body uses to combat viral infections. Let us review it one more time. The first is the innate system which offers a first line of defense by preventing pathogens from taking hold if they enter the body. This is what can prevent you from being infected in the first place. The second system is the adaptive system where once a pathogen has taken hold, the body develops a specific response to the pathogen. This includes both antibody responses as well as cell-mediated responses. Boosting NAD has shown benefits in both the innate system as well as the adaptive system. As adults get older both immune systems decline along the same time frame that NAD declines in the body. The bottom line is that the NAD has direct effects on the Sirtuin Pathways which seem to influence most of the other pathways in the body. We must also remember that NAD+ is of prime importance in the production of ATP. All cells need ATP as a source of energy. NAD+ itself is also used by various enzymes to repair DNA damage. Here is an illustration of NAD benefits.
GENERAL INTRAVENOUS THERAPY
At most of the med-spas, when you ask the employees about how various IV therapies work they state that it improves the immune system and makes one feel better. But when pressed as to how it improves the immune system they are hard pressed to give an answer. We give the answers below.
We have a wide variety of intravenous methods to boost immunity. I will mention a few of them. We have already mentioned NAD given via an IVroute. NAD has far ranging impacts on various functions in the body including our immune system. Another type of intravenous therapy is called Myers cocktail. Myers’ Cocktail is a formula of intravenous vitamins and minerals that was pioneered by the late Dr. John Myers, MD. The “Cocktail” includes magnesium, calcium, B-vitamins (including B12), and Vitamin C and is given by a slow IV push or slow infusion to achieve concentrations of nutrients that are not obtainable with oral administration. It appears that this cocktail will hopefully increase one ability to respond to immune challenges. The vitamin C is especially important. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. We always hear Vitamin C is helpful but what is the real mechanism of action? Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils (WBCs), and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial and viral killing. We have other similar intravenous therapies that seem to boost immunity. These are more or less variations of the Myers cocktail but seem to have more effects on the immune system.
Another type of intravenous formula is called Immune Boost. This is somewhat similar but yet different than Myers cocktail. One thing they all have in common is Vitamin C. The following shows the multitude of Vitamin C benefits. We must realize that when you are sick you need a good bit more Vitamin C. The best benefit from Vitamin C is when it is in your blood, hence IV route. There are some studies in China that seem to support the use of Vitamin C in Covid 19 virus. Will Vitamin C cure the Covid -19 probably not, but it should be able to alter its course for the better. I have a diagram on the various aspects Vitamin C has upon the body’s immune system.
Another aspect of our IV therapy involves Glutathione. This powerful antioxidant is one of most protective molecules in the human body. There are two different forms of glutathione: reduced glutathione (GSH, or L-glutathione), which is the active form, and oxidized glutathione (GSSG), the inactive form. As GSH patrols the cellular environment and puts out oxidative “free radical” fires, it becomes oxidized itself and inactive, thus turning into GSSG. Fortunately, inactive GSSG can be recycled back into the active GSH form, thanks to an enzyme called glutathione reductase. When this enzyme is overwhelmed and too much oxidized GSSG accumulates (as compared to the active GSH), your cells become susceptible to damage. Glutathione is such an important antioxidant to the human body that a scientific study suggests that the abundance of glutathione in the cells can help predict the life expectancy of that human. Glutathione has also been shown to be a powerful anti-inflammatory agent because it inhibits the production of most inflammatory cytokines. Glutathione can also help repair cells that were damaged by radiation, pollutants, stress, infection, and a range of other ailments. Surprisingly enough, glutathione can also slow the process of aging in the cells. As we age, our cells begin to lose their ability to self-repair and to produce strong antioxidants. Increasing our intake of glutathione can help replenish or replace the antioxidants lost from aging and slow down the aging and deterioration of our cells and aid in the self-repair of the cells to prolong their functionality and lifespan. As an antioxidant, glutathione removes oxygen radicals from the body which can harm other cells in the body and cause disease and deterioration. While vitamins C and E are also antioxidants, glutathione has the added benefit of already living within each of your cells allowing it to perfectly placed to do its job. One problem with glutathione is that it has a poor oral absorption rate. It is well absorbed when given via an intravenous route.
WHY IS OUR IV THERAPY UNIQUE?
What will make our IV therapy unique is that we will add some unique products to our IV formulas. We will include some cytokines in very small dosages. For instance, one of these is GCSF. GCSF is called granulocyte colony stimulating factor. GCSF acts in a similar method as to a medicine called Neupogin. Neupogin is a medicine given to patients who have taken chemotherapy and their blood count became low. It especially helps to build up their white blood cell count (WBCs). Remember, WBCs fight viruses. We will give the GCSF in a few different ways. We have an oral form that is absorbed under the tongue, we can deliver it via a patch which utilizes a weak electrical current and is called iontophoresis. Lastly, we will give some low dose intra venous therapy.
Another addition is IFNγ, or type II interferon. It is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages. The importance of IFNγ in the immune system stems in part comes from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNγ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops. Again, we can deliver this a few different ways to the patient.
The last product I would to mention is one called Immunexx. Like some of the other cytokines, this is a compound made by the Canadian company we are working directly with called Viatrexx. Immunexx is an interesting compound. It has a number of interesting components that seem to be significant immune boosters. Again, this can be delivered to the patient in a number of different ways. We also produce our own blend of cytokines that seem to promote healing etc. We have been using this for uyears with excellent success.
MEDICATIONS AND SUPPLEMENTS
We certainly recommend good multi-vitamins. However, we have some specific recommendations when it comes to immune boosting. Luckily, we have access to some of these.
- VITAMIN C 5g/day (25mg/pound
- N-ACETYLCYSTEINE 600mg/day
- GLUTATHIONE 500mg/day
- VITAMIN D 5000IU/day
- ZINC is a mineral that’s commonly added to supplements and other healthcare products like lozenges that are meant to boost your immune system. This is because zinc is essential for immune system function. Zinc is needed for immune cell development. A deficiency in Zinc significantly affects your immune system’s ability to function properly, resulting in an increased risk of infection and disease, including pneumonia.
- Oral NAD 600mg/day
- ELDERBERRY SYRUP 1 tsp/day
- UMCKA (Pelargonium sidoides) An herbal remedy of a species of South African geranium, Umcka plays a role in the production of a specialized protein, called cytokines, that may protect the body’s cells from viral infection.
- BETA GLUCANS effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.
- RED MARINE ALGAE: seems to have antiviral properties. Dosages depends upon the brand.
- CURCUMIN. Curcumin is the main active compound in turmeric. It has powerful anti-inflammatory properties, and animal studies indicate that it may help improve immune function
- LICORICE contains more than 20 triterpenoids and nearly 300 flavonoids. Triterpenoids are widely found in plants. It is found that triterpenoids have a variety of pharmacological activities including anti-inflammatory, anti-diabetic, anti-cancer, regulation of immune function, etc. Among them, only two triterpenes, GL and GA have been reported to have antiviral effects. They can weaken virus activities by inhibiting virus gene expression and replication, reducing adhesion force and stress, and reducing HMGB1 binding to DNA.
- Medicinal mushrooms have been used since ancient times to prevent and treat infection and disease. Many types of medicinal mushrooms have been studied for their immune-boosting potential. Over 270 recognized species of medicinal mushrooms are known to have immune-enhancing properties.
I am sure that I can more to the list but this should suffice for now. The above is in addition to the supplements that one takes to maintain general health. For instance, mine would include Neo-40 (nitric oxide supplement), Resveratrol, Pterostilbene, Green tea extract, and StemXcell, and some other supplements.
SENSECENT CELLS AND SENOLYTIC AGENTS
Cellular senescence is a phenomenon characterized by the cessation of cell division. A senescent cell is one that should have died but did not. It can act like a zombie in the body. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things. Aging and senescent cells have a great impact in both innate and adaptive immune systems. This is a process known as immunosenescence which I have already spoken about. Immunity declines during aging, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. We are aware that induction of senescence alters leukocyte, and specifically T cell, function. An effective immune response against viral infections depends on the activation of cytotoxic T cells that can clear infection by killing virus-infected cells. So, the bottom line is if we can eliminate some senescent cells it would probably make our immune systems function better. Remember, our immune system is responsible for removing senescent cells. If we can take away some of this burden than our immune system will function more efficiently. However, it is important to retain some senescent cells. I strongly advise people to take at least an over the counter senolytic agent on a temporary basis. Make sure these compounds contain Fisetin, Quercetin, and Piperlongumine. In our office we use some very powerful senolytic agents. These include quercetin and a medication which we are using off label.
The FDA has issued an emergency authorization of the anti-malaria drug Hydroxychloroquine for Covid-19 virus. Although the evidence seems to be anecdotal, there does appear to be efficacy. I ordered the dosages for myself and my family. I have also included a dosage of a Z-pack (Azithromycin). I would recommend the Hydroxychloroquine to be taken if one tests positive or if one has symptoms of Covid -19 virus. The dosage should be two tabs twice a day on the first day followed by one tablet twice a day for five days. The Z pack should be started at the same time.
Another aspect of medications includes certain peptides. Peptides are naturally occurring biological molecules. Peptides are found in all living organisms and play a key role in all manner of biological activity. Some of the peptides we will utilize include Thymosin alpha-1 and Thymosin Beta 4. Thymosin alpha-1 is the most recommend peptide for immune stimulation. This should be used as a treatment adjuvant and a prophylactic aid that can help with many conditions beyond viral illness! Most will dose it at 450mcg daily. Thymosin Beta-4 stimulates Natural killer (NK) cells which are essential for defense against tumors and virus-infected cells. These cells are activated in by INF-Gamma. IFN-gamma is activated by IL-18 which TB4 upregulates. Thus, TB4 has been studied for many immune related diseases. One other peptide to consider is LL-37. This is a peptide made by mesenchymal stem cells. It is a very strong bactericidal and viricidal agent.
There are some biologics that are currently under consideration. Remdesivir is a broad-spectrum antiviral drug that interferes with a virus’ ability to replicate. It was originally developed to treat Ebola but had only limited success. However, a study from 2017 showed that remdesivir was able to successfully stop SARS and MERS — sister coronaviruses to the new strain — in both human cells and animal models. In February, Chinese scientists found that remdesivir successfully blocked the novel coronavirus, SARS-CoV-2, from replicating in human cells. Lopinavir and ritonavir, an antiviral drug combination was initially developed to treat HIV, but it turns out it works on other viruses as well. The drugs are given together because lopinavir breaks down very quickly on its own, and it lasts longer when paired with ritonavir. Similar to chloroquine and remdesivir, scientists discovered in 2004 that lopinavir was moderately effective at stopping the original SARS virus from replicating in human cells. When given in combination, lopinavir and ritonavir also helped treat SARS in human patients. There is also talk of utilizing some of the biologics that are used for autoimmune diseases.
A simple and promising treatment which is being considered is the use of the Contrad anti-inflammatory patches (AI). I use these in my stem cell practice on a daily basis. These patches are revolutionary. They are registered with the FDA. They have very powerful anti-inflammatory agents which can be of great importance in the face of pulmonary problems resulting from a cytokine storm. These are patches which will have the gel placed on a patch and then they are placed on the lung and left for about 6-8 hours. The gel contains penetrating molecules which drive the cytokines down deep. There are currently some studies going on the Milan Italy using these patches. From what I am hearing there seems to be some promising results.
PERIPHERAL BLOOD STEM CELLS
This is a type of stem cell coming from the patient. It is found in the blood and is prepared in a propriety method. What is of significance here is that these cells seem to make the immune system younger and healthier. Remember, the reason why some people exposed to the virus never get ill is because of their immune system. As I said earlier a healthy immune system is a healthy patient. One major effect that these cells have on the immune system is that they will make the telomeres of the immune system cells longer. Remember, the telomeres are found at the end of the DNA strand. The shorter the telomere the less effective the cell would be in performing its tasks. Longer telomers will most of the time either prevent or ameliorate many different health issues including viral infections by virtue of making the immune system healthier. Remember what we said about immunosenescence. Short telomeres cause senescent cells to form. So, these peripheral blood stem cells can certainly be a potent weapon in the battle against the Covid-19 virus. The process is quite simple. First, on day one we stimulate the bone marrow to release large number of the cells into the circulation. On day two the blood is taken from the patient and is processed. On day three the cells are given back to the patient and hopefully perform their magic behind the scenes.
WHAT HAVE I DONE, WHAT AM I DOING, WHAT WILL I DO???
- I am faithful in doing my exercises everyday
- I practice the precautions recommended by the CDC including wearing a mask and gloves whenever leaving home. Also follow social distancing
- I take my supplements including a number on the list. It is about a handful every day. I will make sure that I take extra CURCUMIN.
- I have recently received IV vitamin C, NAD, and GLUTATHIONE. I will probably get more of the same. It is probably not a bad idea to get IV Vitamin C on a weekly basis for the next few weeks
- I have done an EBO2 and Peripheral blood stem cell treatment within the last few weeks. I intend to give myself another EBO2 in the near future.
- A few weeks ago, I took my senolytic agents so we are good there.
- If I become symptomatic or I suspect an exposure. I will take Hydroxychloroquine and a Z pack, take higher doses of vitamin C and NAD including intravenous delivery. I will perform another EBO2.
- I will take Berberine to help control my blood sugar.
- If I become symptomatic in chest area will use the AI patches. The results from Milan seem to be very promising
- CUT OUT ALL SUGARS!!!! All they will do is add to the inflammation of the immune system.
- I will go on the oral cytokine formula that we give to most of our patients
- Also, it would not be a bad idea to pray.
HOW ABOUT IMMUNITY??
How well a person’s immune system remembers SARS-CoV-2 is called immune memory. It helps our bodies avoid reinfection by a bug we’ve had before. Immune memory influences the potency of life-saving treatments and vaccines. For now, in people who have had the Covid-19 virus, it appears unlikely that they will get it again. But, and this is a big but, we cannot say for sure. When a pathogen breaches the body’s barriers, the immune system will churn out a variety of immune molecules to fight it. One subset of these molecules, called antibodies, recognizes specific features of the bug in question and mounts repeated attacks until the invader is purged from the body. Antibodies can also be a way for clinicians to tell if a patient has been recently infected with a given pathogen, even when the microbe itself can no longer be detected.
COVID-19 packs a stronger punch than the common cold, so antibodies capable of fending off this new coronavirus may have a shot at lingering longer. Typically, the more severe the disease, the more resources the body will dedicate to memorizing that pathogen’s features resulting in a stronger and longer lasting the immune response. Complicating matters further is the biology of SARS-CoV-2 itself. Viruses aren’t technically alive. They contain genetic instructions to make more copies of themselves but they lack the molecular tools to execute the steps to reproduce. Therefore, they must hijack living cells to complete the replication process. After these pathogens infect cells, their genomes (genetic material) often duplicate sloppily, leading to frequent mutations that persist in the new copies. Most of these changes are inconsequential or lead to revolutionary dead ends. Occasionally, however, mutations will alter a viral strain so substantially that the immune system can no longer recognize it and subsequently sparking an outbreak even in populations that have seen a previous version of the virus before. Viruses in the influenza family are the poster children for these transformations which is in part of why scientists create a new flu vaccine every year.
WHERE DOES THE ANSWER TO CONQUERING THE COVID-19 LIE?
These next two diagrams most likely hold the solution to defeating the Covid-19 virus. The solution to the virus lies in one or more of these pathways. These diagrams represent the stem cell aging pathways. REMEMBER HOW STEM CELLS AGE IS HOW WE AND OUR IMMUNE SYSTEM AGES.
MORE IMPORTANTLY, I HAVE A SAYING I USE IN MY LECTURES “CELLS NOT DOCTORS HEAL PATIENTS”. We can manipulate the cells in methods I have already mentioned but ultimately, THE CELL WILL HEAL THE BODY.
No one knows for sure which pathways are involved. Most all of the techniques and procedures mentioned in this report will affect certain of these pathways. The answer is right before our eyes in these two diagrams. These diagrams represent the cause and solution to the Covid-19 virus. How these pathways are stimulated can mean health or sickness!!
Manipulate these pathways and you will manipulate the immune system. Some food for thought!!
This is another scheme of the pathways.
The next diagram gives a view of the various subpopulations that are affected by the Covid-19 virus.
A FINAL COMMENT OR TWO.
We have been practicing telemedicine for a number of years now so we are still a phone call away to discuss concerns and questions.
IN THE BIT OF LEVITY, there is a good song that seems to sum up times: THIS IS THE OLD CHUCK BERRY SONG The title of it is “RIDDING AROUND IN MY AUTOMOBILE, LISTENING TO THE RADIO, WITH NO PARTICULAR PLACE TO GO” Seems to be a good song for the times where we have stay at home orders with no place to go !!!!
Stay safe and practice CDC RECOMMENDATIONS and consider some of these other options. Please realize that these statements have not been evaluated by the FDA.
– DR. P
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