What if aging wasn’t just an inevitable decline, but something we could slow down or even begin to reverse? That’s exactly what new research is suggesting. Scientists are discovering that by targeting just a few key molecules in the blood, we may be able to rejuvenate tissues, reduce inflammation, and support a longer, healthier life.
Two of the most important players in this process are:
- TGF-β (Transforming Growth Factor Beta): a signaling protein that increases as we age and drives inflammation and tissue breakdown.
- Oxytocin: a hormone that naturally declines over time and plays a role in healing, cognition, and emotional well-being.
When researchers administered small amounts of a TGF-β inhibitor alongside oxytocin, they saw something remarkable. Inflammation was reduced, memory improved, and brain, liver, and muscle function became healthier. Even more impressive, these results were achieved faster and with fewer side effects than when either compound was used on its own.
This approach builds on the groundbreaking research of Irina and Michael Conboy, who have studied how Therapeutic Plasma Exchange (TPE), a procedure that removes old plasma from the blood, can reduce markers of aging and restore tissue health. Their work shows that the key isn’t adding anything new but simply removing what no longer serves us. Specifically, proteins like TGF-β that increase with age and contribute to cellular decline.
What Is Therapeutic Plasmapheresis?
Plasmapheresis is a medical procedure that separates and removes the plasma, the liquid portion of your blood, while returning your blood cells mixed with a clean replacement fluid. Plasma carries important proteins, antibodies, and signaling molecules like TGF-β. When those molecules become unbalanced, especially with age or illness, they can cause more harm than good.
At PUR-FORM, we’ve developed a specialized protocol that uses plasmapheresis to reduce harmful proteins like TGF-β. The goal is to reset your internal environment and support healthier aging at a foundational level.
Why Is TGF-β a Problem?
TGF-β plays a critical role in healing and immune function, but too much of it can cause long-term issues. As levels rise with age, this protein contributes to:
- Chronic inflammation, a major driver of age-related disease
- Fibrosis, or scarring of tissue in organs like the liver and lungs
- Reduced tissue repair, slowing the body’s ability to regenerate
By removing excess TGF-β, we can reduce inflammation, improve tissue function, and help the body return to a more youthful state. Research from the Conboy lab at UC Berkeley has shown that plasmapheresis in older mice improved memory, reduced inflammation, and enhanced tissue repair.
Plasmapheresis: Expanding Beyond Traditional Use
Plasmapheresis has traditionally been used to treat autoimmune and neurological disorders by clearing harmful immune proteins. But today, this powerful therapy is being explored for a much broader purpose. In particular, it shows promise for:
- Reducing chronic inflammation
- Supporting healthy tissue repair
- Potentially reversing biological aging markers
Enhancing Results with Targeted Supplementation
While plasmapheresis offers significant benefits on its own, combining it with targeted supplements can enhance results even further. Many natural compounds have been shown to support TGF-β regulation and overall cellular health. At PUR-FORM, we offer these in both oral and intravenous forms for optimal impact.
Natural Compounds That Inhibit TGF-β
- Resveratrol (150–500 mg/day): reduces fibrosis and supports anti-aging pathways
- Berberine (500 mg, 2–3 times/day): reduces inflammation and supports metabolic health
- Curcumin (500–1,000 mg/day with piperine): helps block TGF-β1 and reduces scarring
- Alpha-Ketoglutarate (1–2 g/day): associated with longer lifespan and improved cell health
Additional supportive nutrients include:
- Spirulina
- Alpha-Lipoic Acid
- Ferulic Acid
- Broccoli sprout powder (sulforaphane)
- Melatonin
- High-dose biotin
These nutraceuticals work together to reduce inflammation and create an internal environment more conducive to longevity and regeneration.
Addressing More Than Just TGF-β
Our protocol also targets key inflammatory molecules linked to aging.
Interleukin-1 Beta (IL-1β):
This inflammatory protein plays a major role in chronic inflammation. Vitamin E (specifically alpha-tocopherol) can help block the pathways that produce IL-1β. Research shows that higher doses—around 700 mg per day—can significantly reduce this marker of inflammation.
Interleukin-6 (IL-6):
Another important inflammatory signal, IL-6 is often elevated in people with insulin resistance or metabolic issues. Vitamin E has also been shown to help lower IL-6 levels in these individuals.
Connective Tissue Growth Factor (CTGF):
This molecule is involved in scarring and tissue fibrosis. Nutrients like leucine, curcumin, resveratrol, and fisetin help regulate the TGF-β pathway, which in turn reduces the production of CTGF and helps minimize fibrosis.
By addressing multiple inflammatory pathways at once, our protocol is designed to reduce chronic inflammation and support your body’s ability to heal and regenerate naturally.
Supporting Oxytocin: The Other Side of the Equation
Oxytocin is best known as the “bonding hormone,” but it also plays a critical role in healing, cognition, and emotional well-being. Unfortunately, it declines with age.
To address this, we include intranasal oxytocin spray in our protocol. It delivers safe and effective doses directly to the brain and is well-tolerated by older adults.
- Dose: 24 IU twice daily
- Duration: 4-week cycles, with monitoring
- Benefits: Improved tissue repair, cognitive support, and mood stabilization
- Safety: Minimal side effects when used as directed
By restoring oxytocin while lowering TGF-β and other inflammatory markers, we can create a more balanced, regenerative environment in the body.
Is Plasmapheresis Right for You?
Plasmapheresis is generally safe when performed in a clinical setting. While traditionally used for certain diseases, research now points to its expanding role in optimizing healthspan and longevity.
If you are looking to reduce inflammation, support tissue repair, and take a proactive role in how you age, this therapy may be a valuable part of your long-term wellness plan.
– Dr. Purita
