We’re excited to share that recent changes in Florida regulations now allow PUR-FORM to offer advanced exosome therapy to our patients. This breakthrough enables us to provide a cutting-edge regenerative treatment that has demonstrated promising results in clinical applications worldwide.
What makes exosome therapy at PUR-FORM truly unique is our proprietary Photobiomodulation (PBM) enhancement process, which we helped develop to optimize exosome potency and therapeutic effectiveness. This innovative approach enhances the natural healing properties of exosomes before they are administered.
We have also integrated exosome therapy into a range of our existing procedures and IV modalities, allowing us to create comprehensive treatment protocols tailored to each patient’s needs. As one of the first practices in our region to offer both intravenous and intra-articular exosome therapy under the new guidelines, and the only one combining it with advanced Photobiomodulation, we are proud to provide this innovative, minimally invasive option for patients seeking alternatives for chronic pain, joint degeneration, and systemic inflammatory conditions.
What Are Exosomes?
Exosome therapy is an advanced regenerative treatment that works by supporting your body’s natural healing processes.
Exosomes are tiny particles (40–180 nanometers in size) naturally released by cells, especially mesenchymal stem cells (MSCs). They act as messengers between cells and carry powerful biological materials such as growth factors, proteins, cytokines, and genetic instructions that help coordinate tissue repair and reduce inflammation.
Unlike traditional stem cell therapy, exosome treatment does not involve live cells. This eliminates concerns about uncontrolled cell growth, tumor formation, and complex storage requirements while maintaining comparable, or in some cases superior, therapeutic effects.
Because of their small size, exosomes can cross important biological barriers, including the blood–brain barrier, making them particularly valuable for neurological conditions, systemic inflammation, and localized tissue damage.
PUR-FORM’s Photobiomodulation Enhancement Process
A Proprietary Advancement in Exosome Therapy
At PUR-FORM, we offer a unique advantage: proprietary Photobiomodulation (PBM) enhancement of exosomes.
Through our involvement in developing this process, we use specific light wavelengths to enhance the therapeutic potential of exosomes before they are administered.
Direct Light Activation of Exosomes
Our PBM protocol exposes purified exosomes to carefully calibrated light wavelengths. This light treatment triggers molecular changes that enhance their regenerative capabilities beyond standard preparations.
Research has demonstrated that PBM-enhanced exosomes may show:
- Up to a 7-fold increase in their ability to promote new blood vessel formation (angiogenesis), which is critical for healing
- Significant increases in beneficial microRNA content, with some therapeutic microRNAs increasing 100-fold or more
- Enhanced wound healing and tissue regeneration compared to standard exosomes
- Improved activity of growth factors and signaling molecules
The Science Behind Light Enhancement
When exosomes absorb specific wavelengths of light, subtle photochemical reactions enhance their biological activity. This process enriches them with beneficial proteins and genetic material, optimizing their ability to deliver healing signals to target tissues.
Importantly, PBM does not introduce foreign substances or genetic modifications. It simply uses light energy to amplify the natural regenerative potential of exosomes.
Why This Matters for Your Treatment
By receiving PBM-enhanced exosomes at PUR-FORM, you benefit from:
- Greater healing potential compared to standard preparations
- Enhanced effectiveness in reducing inflammation and supporting tissue repair
- Access to a technology available at only a limited number of regenerative practices
- An approach supported by peer-reviewed research
This reflects our commitment to offering the most advanced and scientifically supported exosome therapy available.
Intravenous Exosome Therapy
How IV Administration Works
Intravenous (IV) delivery allows exosomes to circulate throughout the body via the bloodstream, reaching multiple organ systems and areas of inflammation or injury.
Treatment typically involves a slow infusion over 30–60 minutes under clinical supervision. Initial treatments are generally spaced 2–4 weeks apart, depending on your condition.
Clinical Applications of IV Exosome Therapy
IV exosome therapy is being used in clinical settings for:
- Neurological conditions such as stroke recovery, neurodegenerative disease, spinal cord injury, and traumatic brain injury
- Cardiovascular recovery following heart attack
- Autoimmune and systemic inflammatory disorders
- Chronic inflammatory lung conditions such as COPD and pulmonary fibrosis
- Anti-aging and cellular wellness support
Safety Profile
Clinical research has demonstrated a favorable safety profile. Investigators have reported no dose-limiting toxicities in multiple studies. The most common side effect is a mild, short-lived fever.
MSC-derived exosomes appear less likely to trigger immune reactions than whole-cell therapies and carry minimal risk of abnormal tissue growth.
Intra-Articular Exosome Therapy
How Joint Injections Work
Intra-articular therapy delivers exosomes directly into the joint space through a precise injection. This targeted approach concentrates regenerative factors where they are most needed.
Clinical Applications for Joint Health
This therapy is commonly used for:
- Osteoarthritis: supporting cartilage repair and improving mobility
- Sports injuries: aiding tendon and ligament healing
- Degenerative joint disease: promoting long-term function without simply masking pain
- Post-surgical recovery: supporting healing and reducing inflammation
- Avascular necrosis: encouraging blood vessel and bone regeneration
Treatment Benefits
Joint-specific therapy offers several advantages:
- Minimally invasive
- Focused regenerative support
- Potential for long-lasting improvement
- Minimal downtime
- Targeted delivery to affected tissues
Dosing and Treatment Protocols
Intravenous Dosing
IV protocols typically range from 15–250 billion exosomes per infusion. The exact dose depends on your condition, body weight, and treatment goals.
Intra-Articular Dosing
Joint injections typically involve approximately 2 billion particles per treatment, administered weekly or biweekly depending on severity.
Your treatment plan will be individualized during your consultation.
Synergistic Benefits: IV Exosomes After EBO2 and Plasmapheresis
Administering IV exosomes after EBO2 (Extracorporeal Blood Oxygenation and Ozonation) or plasmapheresis can enhance regenerative effects.
These therapies help:
- Remove inflammatory proteins and toxins
- Improve oxygen delivery
- Support immune balance
By reducing inflammatory burden first, we create a “clean slate,” allowing exosomes to function more effectively.
This approach may be especially beneficial for autoimmune conditions, chronic inflammatory disorders, and complex degenerative diseases.
Enhancing Exosome Therapy: Synergistic IV Combinations
We have developed advanced combination protocols that pair exosomes with complementary IV therapies to maximize results.
These include:
- Methylene Blue
- NAD+
- Melatonin
- EGCG (Green Tea Extract)
- Curcumin
- High-Dose Vitamin C
- Glutathione
Each therapy either enhances the cellular environment, supports mitochondrial function, reduces inflammation, or improves antioxidant protection, allowing exosomes to work more effectively.
Understanding Exosome Quantities
Exosomes are measured in billions of particles.
Your body naturally contains approximately 6 trillion exosomes circulating at any given time. Therapeutic treatments supplement this natural population with concentrated regenerative signals.
Typical ranges include:
- Anti-aging: 1–5 billion
- Hair restoration: 5–10 billion
- Joint conditions: 10–25 billion
- Neurological conditions: 25–50+ billion
- Systemic IV therapy: 15–250 billion
Research suggests effective dosing ranges between 10 billion and 600 billion particles, with a median effective dose of approximately 43 billion.
Doses are high because exosomes distribute widely, individual cells absorb multiple particles, and exosomes are gradually metabolized over time.
At PUR-FORM, dosing is customized based on your condition and treatment goals.
Safety Considerations and Contraindications
Absolute contraindications include:
- Acute systemic bacterial infection
Relative contraindications requiring individual evaluation include:
- Active malignancy under treatment
We carefully review your medical history to determine whether therapy is appropriate.
What to Expect
During Treatment
IV therapy involves a 30–60 minute infusion while you rest comfortably.
Joint injections take only a few minutes and are performed under sterile conditions.
After Treatment
Most patients experience minimal downtime. Normal daily activities can usually be resumed the same day. Strenuous exercise may be limited for 24–48 hours after joint injections.
Some patients notice improvement within days, while deeper regenerative benefits typically develop over weeks.
Timeline for Results
While individual results vary, many patients experience:
Days 1–7: Reduced inflammation and improved energy
Weeks 2–4: Pain reduction and improved mobility
Weeks 4–8: Continued regenerative progress
Months 3–6: Maximum cumulative benefit
Quality and Safety Standards
We use rigorously tested, purified exosome preparations screened for sterility, safety, and endotoxin levels. Each batch is characterized for particle size, concentration, and bioactivity to ensure consistency.
Is Exosome Therapy Right for You?
Exosome therapy may be appropriate if you are seeking a minimally invasive regenerative approach for:
- Chronic joint pain
- Degenerative conditions
- Systemic inflammation
- Injury recovery
It is most effective when part of a comprehensive plan that may include physical therapy, nutritional optimization, and lifestyle support.
For more information or to schedule a consultation, please contact our office. We are here to help determine whether exosome therapy is right for your regenerative medicine journey.
Regulatory Status
Exosome therapy is an emerging area of regenerative medicine supported by growing research and clinical experience. Exosome products are not currently FDA-approved for the treatment of specific diseases or medical conditions. These statements have not been evaluated by the FDA.
