What Makes You “Old” Isn’t Just Your Birthday
Here’s something fascinating: your chronological age (the number of years you’ve lived) and your biological age (how old your body truly is) can be very different. You might be 50 years old on paper, but your body could function like that of a 70-year-old – or a 40-year-old.
Recent research shows that your biological age is what really determines your health, vitality, and longevity.
A groundbreaking 2024 study published in Antioxidants revealed something remarkable: a simple daily supplement made from three natural compounds reduced participants’ biological age by an average of 11 years in just two months. Let’s take a closer look at what makes these ingredients so effective.
The Study in Simple Terms
Researchers at the Universidad Complutense de Madrid studied 35 healthy adults aged 30 to 63. Half took a supplement containing three natural ingredients – AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) – while the others took a placebo.
Before starting, the participants’ biological age averaged 66 years, even though they were only 46 years old on average. Stress and modern lifestyles likely played a big role in this “accelerated aging.”
After just two months, those taking the supplement showed an 11-year reduction in biological age. More importantly, their bodies didn’t just appear younger on paper – they functioned more like those of younger individuals.
Understanding the Three Key Ingredients
AM3: The Immune System Regulator
AM3 is a natural compound made from carbohydrates and proteins that helps your immune system stay balanced. Rather than simply “boosting” immunity, AM3 keeps your defenses strong but controlled – important as we age and our immune systems become overactive in some areas and sluggish in others.
It helps activate your body’s protective cells, such as macrophages and natural killer cells, while calming harmful inflammation. Research shows it’s safe, well-tolerated, and effective in supporting immune health.
Spermidine: The Cellular Cleanup Crew
Spermidine is a natural molecule found in all living cells, as well as in foods like wheat germ, soybeans, and aged cheese. Unfortunately, spermidine levels drop with age, a change linked to many age-related diseases.
Its main power lies in triggering autophagy, your body’s natural cleaning and recycling system. Think of it as spring cleaning at the cellular level: clearing out damaged parts, removing toxic buildup, and keeping cells youthful and efficient.
Spermidine also protects the heart and brain, supports healthy energy production, and reduces inflammation. People who consume more spermidine-rich foods tend to live longer and healthier lives.
Hesperidin: The Citrus Powerhouse
Hesperidin is a bioflavonoid found in citrus fruits, especially in orange and lemon peels. It’s a strong antioxidant that protects cells from damage caused by oxidative stress, the biological version of rust.
It helps reduce inflammation, supports heart health, and even protects the brain. Hesperidin also improves blood vessel function, lowers blood pressure, and boosts your body’s own antioxidants like glutathione and vitamins C and E.
Together, these effects keep your cells resilient, your circulation healthy, and your brain sharp.
Why These Three Work Better Together
Each ingredient plays a unique role:
- AM3 keeps your immune system balanced.
- Spermidine cleans up cellular waste and restores function.
- Hesperidin protects cells from oxidative and inflammatory stress.
Together, they target the key drivers of aging – immune dysfunction, cellular damage, and inflammation – creating a comprehensive rejuvenation effect.
What Improved in the Study
After two months, participants taking the supplement experienced:
- Stronger immune function – their white blood cells responded faster and more efficiently.
- Better cell communication – their immune systems worked more like those of younger people.
- Lower oxidative stress – the body’s antioxidant defenses improved, reducing cellular “rust.”
- Less inflammation – levels of harmful inflammatory molecules dropped, while calming, protective ones increased.
What This Means for Your Health
Lowering your biological age isn’t just about living longer, it’s about living better. Participants in the study showed measurable improvements that translate to:
- Lower risk of chronic disease
More energy and faster recovery - Stronger immune defenses
Sharper mental clarity and improved quality of life
The study’s authors concluded that this supplement combination could be a safe and effective way to help maintain youthfulness and health over time.
How PurForm Enhances These Results
At PUR-FORM, we integrate advanced regenerative therapies that amplify these supplement benefits.
- Hyperbaric Oxygen Therapy improves oxygen delivery and enhances cellular repair.
- IV NAD+ Therapy boosts energy production and supports the same rejuvenation pathways as spermidine.
- Photobiomodulation (Red Light Therapy) reduces inflammation and stimulates repair.
- EBO2 and Exosome Therapies further optimize immune balance and cellular regeneration.
Each patient at PURFORM receives a personalized protocol based on their unique biological markers and goals. This combined approach, nutrition plus regenerative medicine, offers a true pathway to reversing biological aging.
Practical Takeaways
- Dosage used in the study: AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) daily for two months.
- Food sources: Spermidine is found in aged cheese, mushrooms, soybeans, and wheat germ; hesperidin in citrus fruit peels.
- Results: Significant improvements appeared within two months and may increase with continued use.
The Bottom Line
This landmark study shows that a simple, natural supplement combination can reverse biological aging by more than a decade in just eight weeks.
When paired with the right medical guidance and regenerative therapies, it’s now possible not only to extend lifespan, but to extend healthspan, the number of years lived in vibrant health.
Aging is no longer something we simply accept. It’s a process we can understand, measure, and influence through evidence-based science. With the right tools and guidance, turning back your biological clock is not only possible – it’s achievable.
—Dr. P
